UV Spectrophotometric method for the identification and solubility determination of nevirapine

被引：10
|
作者：
Stieger, N. [1 ]
Liebenberg, W. [1 ]
Wessels, J. C. [1 ]
机构：
[1] North West Univ, Fac Hlth Sci, Unit Drug Res & Dev, ZA-2520 Potchefstroom, South Africa
来源：
PHARMAZIE | 2009年 / 64卷 / 10期
关键词：
DRUGS; HPLC;
D O I：
10.1016/ph.2009.9163
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An UV spectrophotometric method was developed for the quantitative determination of nevirapine in water, methanol and 0.1 N HCl It was found that qualitative determination is also possible, due to a peak-shift observed with 0.1 N HCl. The solubility at 37 degrees C, for both the anhydrous and Hemi-hydrated forms of nevirapine, was determined in each of the three solvents
引用
收藏
页码：690 / 691
页数：2
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