Sulfated Zirconia: An Efficient and Reusable Heterogeneous Catalyst in the Friedel-Crafts Acylation Reaction of 3-Methylindole

被引：8
|
作者：
Vargas, Dario A. [1 ]
Mendez, Leticia J. [1 ,2 ]
Canepa, Alicia S. [1 ]
Bravo, Rodolfo D. [1 ]
机构：
[1] Univ Nacl La Plata, Fac Ciencias Exactas, Ctr Estudio Compuestos Organ, Dept Quim, Calle 47 & 115, RA-1900 La Plata, Buenos Aires, Argentina
[2] CINDECA CONICET UNLP, Fac Ciencias Exactas, RA-1900 La Plata, Buenos Aires, Argentina
来源：
CATALYSIS LETTERS | 2017年 / 147卷 / 06期
关键词：
Sulfated zirconia; 3-Methylindole; Ketones; Recyclability; Acylation reaction; N-SUBSTITUTED; 1-ALKYL; ONE-POT SYNTHESIS; INTRAMOLECULAR SULFONYLAMIDOMETHYLATION; CONVENIENT SYNTHESIS; ACID; 3-ACYLINDOLES; CHLORIDE; INDOLE; 2H-ISOQUINOLIN-3-ONES;
D O I：
10.1007/s10562-017-2057-x
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
An efficient process for the Friedel-Crafts acylation of 3-methylindole with acid anhydrides in the presence of sulfated zirconia was developed. This catalyst shows excellent catalytic activity with good conversion and selectivity towards formation of the products of 2-acylation (3-methyl-1H-indol-2-yl)ketones. Other advantages related to this process are the simple work-up procedure and smaller production of chemical waste. The catalyst was easily recycled and reused with a minimal loss in activity through three reaction cycles. The catalyst was characterized by FT-IR spectroscopy, X-Ray diffraction and superficial acidity.
引用
收藏
页码：1496 / 1502
页数：7
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