Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors

被引：6

作者：

Lucas, Matthew C. ^{[1
]}

Carter, David S. ^{[1
]}

Cai, Hai-Ying ^{[1
]}

Lee, Eun Kyung ^{[1
]}

Schoenfeld, Ryan C. ^{[1
]}

Steiner, Sandra ^{[1
]}

Villa, Marzia ^{[1
]}

Weikert, Robert J. ^{[1
]}

Iyer, Pravin S. ^{[1
]}

机构：

[1] Roche Palo Alto LLC, Palo Alto, CA 94304 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 16期

关键词：

TRI; Triple reuptake inhibitor; Monoamine reuptake inhibitor; Neurotransmitter; Indole; Major depressive disorder; DEPRESSION;

D O I：

10.1016/j.bmcl.2009.06.076

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A variety of novel aminoheterocycle scaffolds as selective monoamine reuptake inhibitors have been prepared and one of these scaffolds is achiral. The main elements responsible for hERG channel, CYP2D6 and CYP3A4 inhibition were identified. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4630 / 4633

页数：4

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