Protective effects of echinocystic acid isolated from Gleditsia sinensis Lam. against acute myocardial ischemia

被引：23

作者：

Wu, Jianming ^{[1
,2
]}

Li, Jian ^{[3
]}

Zhu, Zhiyong ^{[1
]}

Li, Jiang ^{[1
]}

Huang, Guojun ^{[2
]}

Tang, Yao ^{[3
]}

Gao, Xiaoping ^{[1
]}

机构：

[1] Kang Hong Pharmaceut Grp, Chengdu 610036, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China

[3] Sichuan Univ, W China Hosp, Chengdu 610064, Peoples R China

来源：

FITOTERAPIA | 2010年 / 81卷 / 01期

关键词：

Gleditsia sinensis; Echinocystic acid; Myocardial ischemia; Isoproterenol; Vasopressin; Bcl-2; APOPTOSIS; INDUCTION; EXTRACT; MODELS; FRUIT; RATS;

D O I：

10.1016/j.fitote.2009.06.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Echinocystic acid (EA), a pentacyclic triterpene, was isolated and identified from the fruits of Gleditsia sinensis Lam. The protective effects of EA were evaluated in rat models with acute myocardial ischemia induced by isoproterenol and vasopressin. In the electrocardiogram of anesthetized rats, EA prevented the ST-segment depression induced by isoproterenol or vasopressin in a dose-dependently manner. Furthermore, the mRNA expression of Bcl-2 was analyzed by RT-PCR. EA shows an elevation of Bcl-2 mRNA level in infarcted tissue induced by isoproterenol in rats. These results demonstrated for the first time EA has a cardioprotective effect and may be a natural drug. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：8 / 10

页数：3

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