Protective effects of echinocystic acid isolated from Gleditsia sinensis Lam. against acute myocardial ischemia

被引：23
|
作者：
Wu, Jianming [1 ,2 ]
Li, Jian [3 ]
Zhu, Zhiyong [1 ]
Li, Jiang [1 ]
Huang, Guojun [2 ]
Tang, Yao [3 ]
Gao, Xiaoping [1 ]
机构：
[1] Kang Hong Pharmaceut Grp, Chengdu 610036, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China
[3] Sichuan Univ, W China Hosp, Chengdu 610064, Peoples R China
来源：
FITOTERAPIA | 2010年 / 81卷 / 01期
关键词：
Gleditsia sinensis; Echinocystic acid; Myocardial ischemia; Isoproterenol; Vasopressin; Bcl-2; APOPTOSIS; INDUCTION; EXTRACT; MODELS; FRUIT; RATS;
D O I：
10.1016/j.fitote.2009.06.015
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Echinocystic acid (EA), a pentacyclic triterpene, was isolated and identified from the fruits of Gleditsia sinensis Lam. The protective effects of EA were evaluated in rat models with acute myocardial ischemia induced by isoproterenol and vasopressin. In the electrocardiogram of anesthetized rats, EA prevented the ST-segment depression induced by isoproterenol or vasopressin in a dose-dependently manner. Furthermore, the mRNA expression of Bcl-2 was analyzed by RT-PCR. EA shows an elevation of Bcl-2 mRNA level in infarcted tissue induced by isoproterenol in rats. These results demonstrated for the first time EA has a cardioprotective effect and may be a natural drug. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：8 / 10
页数：3
相关论文
共 50 条
  • [1] A new anti-HIV lupane acid from Gleditsia sinensis Lam.
    Li, Wan-Hua
    Zhang, Xiang-Ming
    Tian, Rong-Ren
    Zheng, Yong-Tang
    Zhao, Wen-Ming
    Qiu, Ming-Hua
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2007, 9 (06) : 551 - 555
  • [2] Antibacterial phenolic compounds from the spines of Gleditsia sinensis Lam.
    Zhou, Ligang
    Li, Duan
    Wang, Jingguo
    Liu, Yuanshuai
    Wu, Jianyong
    NATURAL PRODUCT RESEARCH, 2007, 21 (04) : 283 - 291
  • [3] Protective effects and mechanisms of extracts of Gleditsia sinensis Lam. Thorn on DSS-induced colitis in mice
    Liu, Xiaoming
    Chen, Yujie
    Liu, Yong
    Hu, Yang
    Wang, Keke
    Huang, Lixin
    Ke, Xiquan
    Peng, Lei
    Guo, Zhiguo
    JOURNAL OF ETHNOPHARMACOLOGY, 2025, 340
  • [4] Galactomannan from the seeds of chinese honey locust (Gleditsia sinensis Lam.)
    D. N. Oleynikov
    A. V. Rohin
    Applied Biochemistry and Microbiology, 2010, 46 : 103 - 107
  • [5] Galactomannan from the seeds of chinese honey locust (Gleditsia sinensis Lam.)
    Oleynikov, D. N.
    Rohin, A. V.
    APPLIED BIOCHEMISTRY AND MICROBIOLOGY, 2010, 46 (01) : 103 - 107
  • [6] Two ellagic acid glycosides from Gleditsia sinensis Lam. with antifungal activity on Magnaporthe grisea
    Zhou, Ligang
    Li, Duan
    Jiang, Weibo
    Qin, Zhizhong
    Zhao, Shuang
    Qiu, Minghua
    Wu, Jianyong
    NATURAL PRODUCT RESEARCH, 2007, 21 (04) : 303 - 309
  • [7] Evaluation of galactomannan from Gleditsia sinensis Lam. as sustained release material in colonic drug delivery
    Jian, Honglei
    Zhu, Liwei
    Zhang, Weiming
    Qi, Xiang
    Jiang, Jianxin
    ADVANCES IN SUPERALLOYS, PTS 1 AND 2, 2011, 146-147 : 589 - +
  • [8] Echinocystic acid, isolated from Gleditsia sinensis fruit, protects endothelial progenitor cells from damage caused by oxLDL via the Akt/eNOS pathway
    Lai, Peng
    Liu, Yixin
    LIFE SCIENCES, 2014, 114 (02) : 62 - 69
  • [9] Protective effects of acacetin isolated from Ziziphora clinopodioides Lam. (Xintahua) on neonatal rat cardiomyocytes
    Yang, Wei-Jun
    Liu, Chong
    Gu, Zheng-Yi
    Zhang, Xing-Yue
    Cheng, Bo
    Mao, Yan
    Xue, Gui-Peng
    CHINESE MEDICINE, 2014, 9
  • [10] Protective effects of acacetin isolated from Ziziphora clinopodioides Lam. (Xintahua) on neonatal rat cardiomyocytes
    Wei-Jun Yang
    Chong Liu
    Zheng-Yi Gu
    Xing-Yue Zhang
    Bo Cheng
    Yan Mao
    Gui-Peng Xue
    Chinese Medicine, 9
12345