Protein quality control-linking the unfolded protein response to disease Conference on 'From Unfolded Proteins in the Endoplasmic Reticulum to Disease'

被引：7
|
作者：
Cyr, Douglas M. [1 ]
Hebert, Daniel N. [2 ]
机构：
[1] Univ N Carolina, Dept Cell & Dev Biol, Sch Med, Chapel Hill, NC 27599 USA
[2] Univ Massachusetts, Dept Biochem & Mol Biol, Amherst, MA 01003 USA
来源：
EMBO REPORTS | 2009年 / 10卷 / 11期
关键词：
unfolded protein response; protein quality control; molecular chaperone; protein folding; protein degradation; MISFOLDED PROTEINS; STRESS; ERAD; ALPHA-1-ANTITRYPSIN; DEFICIENCY; COMPLEX; CELLS;
D O I：
10.1038/embor.2009.224
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The proper folding of proteins is essential for cellular homeostasis and prevention of an ever‐growing number of diseases. Here, the authors highlight recent breakthroughs in the study of the unfolded protein response and new strategies to combat the diseases caused by its malfunction.
引用
收藏
页码：1206 / 1210
页数：5
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