Lack of the PAC1 receptor alters the circadian expression of VIP mRNA in the suprachiasmatic nucleus of mice

被引：14
|
作者：
Georg, Birgitte [1 ]
Hannibal, Jens [1 ]
Fahrenkrug, Jan [1 ]
机构：
[1] Bispebjerg Hosp, Dept Clin Biochem, DK-2400 Copenhagen NV, Denmark
来源：
BRAIN RESEARCH | 2007年 / 1135卷 / 01期
关键词：
circadian; PAC1-/-; real-time RT-PCR; SCN/suprachiasmatic nucleus; VIP;
D O I：
10.1016/j.brainres.2006.12.001
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
PACAP in the retinohypothalamic tract mediates photic information to the suprachiasmatic nucleus via the PAC(1) receptor. The diurnal and circadian VIP mRNA expressions in the suprachiasmatic nucleus of PAC(1)(-/-) and wild type mice were quantified. During light/dark cycles identical VIP mRNA rhythms were found while the oscillation pattern differed between the two types of animals during constant darkness. The results show that the circadian VIP mRNA expression is influenced by the absence of PAC(1), signalling. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：52 / 57
页数：6
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