Human Papillomavirus Antibody Levels and Quadrivalent Vaccine Clinical Effectiveness in Perinatally Human Immunodeficiency Virus-infected and Exposed, Uninfected Youth

被引：23

作者：

Moscicki, Anna-Barbara ^{[1
]}

Karalius, Brad ^{[2
]}

Tassiopoulos, Katherine ^{[2
]}

Yao, Tzy-Jyun ^{[3
]}

Jacobson, Denise L. ^{[3
]}

Patel, Kunjal ^{[2
]}

Purswani, Murli ^{[4
,7
]}

Seage, George R., III ^{[2
]}

Yogev, Ram ^{[5
]}

Sanders, Margaret Ann ^{[5
]}

Malee, Kathleen ^{[5
]}

Hunter, Scott ^{[5
]}

Shearer, William ^{[6
]}

Paul, Mary ^{[6
]}

Cooper, Norma ^{[6
]}

Harris, Lynnette ^{[6
]}

Purswani, Murli ^{[4
,7
]}

Baig, Mahboobullah Mirza ^{[7
]}

Villegas, Alma ^{[7
]}

Puga, Ana ^{[8
]}

Navarro, Sandra ^{[8
]}

Garvie, Patricia A. ^{[8
]}

Blood, James ^{[8
]}

Burchett, Sandra K. ^{[9
]}

Karthas, Nancy ^{[9
]}

Kammerer, Betsy ^{[9
]}

Wiznia, Andrew ^{[10
]}

Burey, Marlene ^{[10
]}

Shaw, Ray ^{[10
]}

Auguste, Raphaelle ^{[10
]}

Dieudonne, Arry ^{[11
]}

Bettica, Linda ^{[11
]}

Johnson, Juliette ^{[11
]}

Chen, Janet S. ^{[12
]}

Bulkley, Maria Garcia ^{[12
]}

Ivey, Latreaca ^{[12
]}

Grant, Mitzie ^{[12
]}

Knapp, Katherine ^{[13
]}

Allison, Kim ^{[13
]}

Wilkins, Megan ^{[13
]}

Russell-Bell, Jamie ^{[13
]}

Acevedo-Flores, Midnela ^{[14
]}

Rios, Heida ^{[14
]}

Olivera, Vivian ^{[14
]}

Silio, Margarita ^{[15
]}

Gabriel, Medea ^{[15
]}

Sirois, Patricia ^{[15
]}

Spector, Stephen A. ^{[16
]}

Norris, Kim ^{[16
]}

Nichols, Sharon ^{[16
]}

机构：

[1] Univ Calif Los Angeles, Dept Pediat, Div Adolescent Med, Los Angeles, CA 90024 USA

[2] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[3] Harvard TH Chan Sch Publ Hlth, Ctr Biostat AIDS Res, Boston, MA USA

[4] Icahn Sch Med Mt Sinai, Bronx Lebanon Hosp Ctr, Div Pediat Infect Dis, New York, NY 10029 USA

[5] Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL 60611 USA

[6] Baylor Coll Med, Houston, TX 77030 USA

[7] Bronx Lebanon Hosp Ctr, Bronx, NY 10456 USA

[8] Childrens Diagnost & Treatment Ctr, Ft Lauderdale, FL USA

[9] Boston Childrens Hosp, Boston, MA USA

[10] Jacobi Med Ctr, New York, NY USA

[11] Rutgers New Jersey Med Sch, Newark, NJ USA

[12] St Christophers Hosp Children, Philadelphia, PA 19133 USA

[13] St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA

[14] San Juan Hosp, Dept Pediat, Farmington, NM USA

[15] Tulane Univ, Sch Med, New Orleans, LA 70118 USA

[16] Univ Calif San Diego, La Jolla, CA 92093 USA

[17] Univ Colorado, Hlth Sci Ctr, Denver, CO USA

[18] Univ Miami, Coral Gables, FL 33124 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2019年 / 69卷 / 07期

关键词：

HPV vaccine; perinatally HIV infected youth; antibody titers; abnormal cytology; HIV-INFECTION; NEUTRALIZING EPITOPES; PARTICLE VACCINE; YOUNG-WOMEN; US CHILDREN; HPV; IMMUNOGENICITY; RISK; ADOLESCENTS; POPULATION;

D O I：

10.1093/cid/ciy1040

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. Persons who are infected with human immunodeficiency virus (HIV) are at high risk of human papillomavirus (HPV)-associated cancers. The objectives are to compare antibody titers to HPV 6, 11, 16, and 18 and rate of abnormal cytology between perinatally HIV-infected (PHIV) and perinatally HIV-exposed, uninfected (PHEU) youth. Methods. This is a prospective observational cohort study of HPV4 vaccinated youth performed as part of the multicenter Pediatric HIV/AIDS Cohort Study Adolescent Master Protocol. Seroconversion and geometric mean titer (GMT) against HPV types 6, 11, 16, and 18 were calculated. Vaccine effectiveness included rates of abnormal cervical cytology and genital warts. Results. Seroconversion to HPV 6, 11, 16, and 18 occurred in 83%, 84%, 90%, and 62% of 310 vaccinated PHIV youth compared to 94%, 96%, 99%, and 87% of 148 vaccinated PHEU youth, respectively (P < .05 for all comparisons). GMTs were lower in the PHIV vs PHEU within each category of HPV4 doses received. Higher GMTs were associated with younger age, lower HIV type 1 RNA viral load, and higher CD4% at first HPV4 vaccination, as well as shorter duration between last vaccine dose and antibody specimen. Abnormal cytology occurred in 33 of 56 PHIV and 1 of 7 PHEU sexually active vaccinated females, yielding incidence rates per 100 person-years of 15.0 (10.9 to 20.6) and 2.9 (0.4 to 22.3), respectively. Conclusion. Antibody titers to HPV4 were lower for all serotypes in PHIV compared to PHEU youth. Protection against abnormal cytology was also diminished in sexually active PHIV females.

引用

页码：1183 / 1191

页数：9

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