Inflammasome-Associated Nucleotide-Binding Domain, Leucine-Rich Repeat Proteins and Inflammatory Diseases

被引：70
|
作者：
Jha, Sushmita [2 ]
Ting, Jenny P-Y [1 ,3 ]
机构：
[1] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Dept Cell & Mol Physiol, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA
来源：
JOURNAL OF IMMUNOLOGY | 2009年 / 183卷 / 12期
基金：
美国国家卫生研究院;
关键词：
NF-KAPPA-B; INNATE IMMUNE-RESPONSE; MUCKLE-WELLS-SYNDROME; NALP3; INFLAMMASOME; IRAK-4; INHIBITORS; CIAS1; MUTATIONS; DANGER SIGNAL; CASPASE-1; ACTIVATION; MURAMYL DIPEPTIDE; CUTTING EDGE;
D O I：
10.4049/jimmunol.0902425
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The nucleotide-binding domain, leucine-rich repeat (NLR) proteins a-re a recently discovered family of intracellular pathogen and danger signal sensors. NLRs have emerged as important contributors to innate immunity in animals. The physiological impact of these genes is increasingly evident, underscored by the genetic association of variant family members with an array of inflammatory diseases. The association of mutations in NLR genes with autoinflammatory diseases indicates an important function of these genes in inflammation in vivo, This review summarizes the role of the inflammasome NLR proteins in innate immunity and inflammatory diseases and explores the possible utility of some of these NLRs as pharmacological targets. The Journal of Immunology, 2009, 183: 7623-7629.
引用
收藏
页码：7623 / 7629
页数：7
相关论文
共 50 条
  • [21] Silencing of a Unique Integrated Domain Nucleotide-Binding Leucine-Rich Repeat Gene in Wheat Abolishes Diuraphis noxia Resistance
    Nicolis, Vittorio
    Venter, Eduard
    MOLECULAR PLANT-MICROBE INTERACTIONS, 2018, 31 (09) : 940 - 950
  • [22] Nucleotide-binding leucine-rich repeat proteins: a missing link in controlling cell fate and plant adaptation to hostile environment?
    Huang, Feifei
    Wu, Feihua
    Yu, Min
    Shabala, Sergey
    JOURNAL OF EXPERIMENTAL BOTANY, 2022, 73 (03) : 631 - 635
  • [23] Contribution of Duplicated Nucleotide-Binding Leucine-Rich Repeat (NLR) Genes to Wheat Disease Resistance
    Hao, Yongchao
    Pan, Yinghua
    Chen, Wuying
    Rashid, Muhammad Abdul Rehman
    Li, Mengyao
    Che, Naixiu
    Duan, Xu
    Zhao, Yan
    PLANTS-BASEL, 2023, 12 (15):
  • [24] Dynamic Nucleotide-Binding Site and Leucine-Rich Repeat-Encoding Genes in the Grass Family
    Luo, Sha
    Zhang, Yu
    Hu, Qun
    Chen, Jiongjiong
    Li, Kunpeng
    Lu, Chen
    Liu, Hui
    Wang, Wen
    Kuang, Hanhui
    PLANT PHYSIOLOGY, 2012, 159 (01) : 197 - 210
  • [25] Initial periodontal treatment affects nucleotide-binding domain leucine-rich repeat-containing protein 3 inflammasome priming in peripheral blood mononuclear cells
    Higuchi, Kanako
    Ziauddin, S. M.
    Yamashita, Yasunori
    Ozaki, Yukio
    Yoshimura, Atsutoshi
    ARCHIVES OF ORAL BIOLOGY, 2020, 110
  • [26] INVOLVEMENT OF THE NON-INFLAMMASOME FORMING NUCLEOTIDE-BINDING DOMAIN LEUCINE-RICH REPEAT PROTEIN 12 (NLRP12) IN MURINE VISCERAL LEISHMANIASIS (VL)
    Valadares, Diogo
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2018, 99 (04): : 404 - 404
  • [27] NOD-like subfamily of the nucleotide-binding domain and leucine-rich repeat containing family receptors and their expression in channel catfish
    Sha, Zhenxia
    Abernathy, Jason W.
    Wang, Shaolin
    Li, Ping
    Kucuktas, Huseyin
    Liu, Hong
    Peatman, Eric
    Liu, Zhanjiang
    DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2009, 33 (09): : 991 - 999
  • [28] Calcium channels at the center of nucleotide-binding leucine-rich repeat receptor-mediated plant immunity
    Shitou Xia
    Xueru Liu
    Yuelin Zhang
    JournalofGeneticsandGenomics, 2021, 48 (06) : 429 - 432
  • [29] Calcium channels at the center of nucleotide-binding leucine-rich repeat receptor-mediated plant immunity
    Xia, Shitou
    Liu, Xueru
    Zhang, Yuelin
    JOURNAL OF GENETICS AND GENOMICS, 2021, 48 (06) : 429 - 432
  • [30] A Role for the Human Nucleotide-binding Domain, Leucine-rich Repeat-containing Family Member NLRC5 in Antiviral Responses
    Neerincx, Andreas
    Lautz, Katja
    Menning, Maureen
    Kremmer, Elisabeth
    Zigrino, Paola
    Hoesel, Marianna
    Buening, Hildegard
    Schwarzenbacher, Robert
    Kufer, Thomas A.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (34) : 26223 - 26232
12345