Inhibition of recombinant GluN1/GluN2A and GluN1/GluN2B N-methyl-D-aspartate receptors by single malt whiskies

被引：0
|
作者：
Otton, Hannah J. [1 ]
Janssen, Ariane [1 ]
Wyllie, David J. A. [1 ]
机构：
[1] Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2009年 / 37卷
关键词：
ethanol; gamma-aminobutyric acid type A receptor (GABA(A)R); glutamate; glycine; malt whisky; N-methyl-D-aspartate receptor (NMDAR); XENOPUS-LAEVIS OOCYTES; NMDA RECEPTORS; ETHANOL; SUBTYPES; ALCOHOL;
D O I：
10.1042/BST0371423
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
NMDARs (N-methyl-D-aspartate receptors) are considered to be a target for the inhibitory actions of ethanol. While profound inhibition of both native and recombinant NMDARs can be observed following the application of high concentrations of ethanol the levels of inhibition seen with lower concentrations of ethanol are more modest. Here, we report the effects of inhibiting NMDAR-mediated responses with ethanol concentrations that are experienced during the social consumption of alcohol comparing levels of inhibition seen with 'pure' ethanol with those produced by ethanol contained in three popular single malt whiskies.
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收藏
页码：1423 / 1425
页数：3
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