New catalytic system for the synthesis of imidazo[1,2-a]pyridines by the Ugi reaction

被引：15

作者：

Mironov, M. A. ^{[1
]}

Tokareva, M. L. ^{[1
]}

Ivantsova, M. N. ^{[1
]}

Mokrushin, V. S. ^{[1
]}

机构：

[1] Ural State Tech Univ, Ekaterinburg 620002, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2006年 / 55卷 / 10期

关键词：

Ugi reaction; isocyanides; imidazo[1,2-a]pyridine; catalysis; combinatorial synthesis; MULTICOMPONENT REACTION;

D O I：

10.1007/s11172-006-0494-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A combination of N-hydroxysuccinimide and p-toluenesulfonic acid is proposed as an efficient catalyst for the preparation of a great variety of imidazo[1,2-a]pyridine derivatives by three-component condensation of aromatic isocyanides, aldehydes, and 2-aminopyridine. The advantages of this procedure are high yields of the target products and the absence of side reactions.

引用

页码：1835 / 1839

页数：5

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