Neomycin production with free and immobilized cells of Streptomyces marinensis in an airlift reactor

被引：44
|
作者：
Srinivasulu, B
Prakasham, RS [1 ]
Jetty, A
Srinivas, S
Ellaiah, P
Ramakrishna, SV
机构：
[1] Indian Inst Chem Technol, Biochem & Environm Engn Ctr, Hyderabad 500007, Andhra Pradesh, India
[2] Andhra Univ, Dept Pharmaceut Sci, Waltair 530003, Andhra Pradesh, India
来源：
PROCESS BIOCHEMISTRY | 2002年 / 38卷 / 04期
关键词：
bioreactor; immobilization; neomycin; Streptomyces marinensis;
D O I：
10.1016/S0032-9592(02)00182-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neomycin production by free and alginate immobilized Streptomyces marinensis cells was investigated in an airlift reactor. Neomycin production was increased two and a half times with immobilized cells. A marginal decrease in neomycin production was noticed with reduced supplementation of carbon source (up to one-fourth concentration). Immobilized S. marinensis particles showed a half-life of 20 days during continuous fermentation in an airlift reactor. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：593 / 598
页数：6
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