Deconstructing protein and gene expression pathways to define the anticancer effects of XPO1 inhibition in ovarian cancer

被引：0
|
作者：
Evans, Brad R. [1 ]
Silvers, Thomas R. [1 ]
Chen, Ying A. [1 ]
Garcia, Jason [1 ]
Camacho, Catalina [1 ]
Sharp, Andrew J. [1 ]
Garag, Paras [1 ]
Koduru, Srinivas V. [2 ]
Billaud, Jean-Noel [3 ]
Halpert, Richard L. [3 ]
Dottino, Peter R. [1 ]
Landesman, Yosef [4 ]
Shacham, Sharon [4 ]
Martignetti, John A. [1 ]
机构：
[1] Icahn Sch Med Mt Sinai, New York, NY 10029 USA
[2] Gene Arrays, New York, NY USA
[3] Qiagen Bioinformat, Redwood City, CA USA
[4] Karyopharm Therapeut Inc, Natick, MA USA
来源：
CANCER RESEARCH | 2015年 / 75卷
关键词：
D O I：
10.1158/1538-7445.AM2015-1758
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
1758
引用
收藏
页数：2
相关论文
共 50 条
  • [31] Letter to the editor regarding "XPO1 inhibition synergizes with PARP1 inhibition in small cell lung cancer by targeting nuclear transport of FOXO3a"
    Liang, Renba
    CANCER LETTERS, 2022, 524 : 193 - 193
  • [32] Combinatorial inhibition of mTOR and exportin-1 (XPO1) represses cell survival via metabolic modulation of pro-survival pathways in mantle cell lymphomas
    Sekihara, K.
    Saitoh, K.
    Yang, H.
    Miida, T.
    Andreeff, M.
    Tabe, Y.
    ANNALS OF ONCOLOGY, 2017, 28
  • [33] Serum Level of WT1 Gene Protein and WT1 Gene Expression in Ovarian Cancer
    Dubey, Harshita
    Ranjan, Amar
    Tanwar, Pranay
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2024, 26 (06): : S55 - S55
  • [34] Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration
    Azmi, Asfar S.
    Li, Yiwei
    Muqbil, Irfana
    Aboukameel, Amro
    Senapedis, William
    Baloglu, Erkan
    Landesman, Yosef
    Shacham, Sharon
    Kauffman, Michael G.
    Philip, Philip A.
    Mohammad, Ramzi M.
    ONCOTARGET, 2017, 8 (47) : 82144 - 82155
  • [35] Wilms tumor gene (WT1) protein expression in epithelial ovarian cancer
    Djordjevic, Biljana
    Vukomanovic, Predrag
    Stojanovic, Simonida
    Velickovic, Ljubinka Jankovic
    HEALTHMED, 2012, 6 (06): : 2128 - 2133
  • [36] Co-expression analysis of transcriptomic data from cancer and healthy specimens reveals rewiring of proteasome genes and an interaction with the XPO1 gene across several tumour types
    Vito Spataro
    Antoine Buetti-Dinh
    Translational Medicine Communications, 9 (1)
  • [37] Altered Gene Expression Profiles Define Pathways in Colorectal Cancer Cell Lines Affected by Celecoxib
    Fatima, Naheed
    Yi, Ming
    Ajaz, Sadia
    Stephens, Robert M.
    Stauffer, Stacey
    Greenwald, Peter
    Munroe, David J.
    Ali, Iqbal Unnisa
    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2008, 17 (11) : 3051 - 3061
  • [38] Selective Inhibitors of Nuclear Export (SINE) CRM1 (XPO1) Antagonists Activate Multiple Tumor Suppressor Pathways and Kill Prostate Cancer (PrCa) Cells
    Festuccia, C.
    Gravina, G. L.
    Mancini, A.
    D'Alessandro, A.
    Chin, L.
    Shechter, S.
    Sandanayaka, V.
    McCauley, D.
    Kauffman, M.
    Shacham, S.
    EUROPEAN JOURNAL OF CANCER, 2012, 48 : S234 - S235
  • [39] Targeting XPO1 Combined with Radiotherapy to Enhance Systemic Anti-tumor Effects in Non-Small Cell Lung Cancer
    Wen, W.
    Qian, L.
    Xie, Y.
    Zhang, X.
    Wang, J.
    Zhou, J.
    Liu, R.
    Yu, J.
    Chen, D.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2023, 117 (02): : E221 - E222
  • [40] Selinexor or KPT-8602 mediated XPO1 inhibition synergizes with dexamethasone to repress convergent pathways in the mTORC1 signaling network and drive cell death in multiple myeloma
    Argueta, Christian
    Kashyap, Trinayan
    Klebanov, Boris
    Chang, Hua
    Friedlander, Sharon
    Baloglu, Erkan
    Landesman, Yosef
    Lee, Margaret
    Gardner, Humphrey
    Shacham, Sharon
    Senapedis, William
    CANCER RESEARCH, 2017, 77
12345