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Dietary inflammatory index and risk of reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma: a population-based case-control study
被引:17
|作者:
Shivappa, Nitin
[1
,2
]
Hebert, James R.
[1
,2
]
Anderson, Lesley A.
[3
]
Shrubsole, Martha J.
[4
]
Murray, Liam J.
[3
]
Getty, Lauren B.
[3
]
Coleman, Helen G.
[3
]
机构:
[1] Univ South Carolina, Canc Prevent & Control Program, Dept Epidemiol & Biostat, Arnold Sch Publ Hlth, Columbia, SC 29208 USA
[2] Connecting Hlth Innovat LLC, Columbia, SC 29201 USA
[3] Queens Univ Belfast, Ctr Publ Hlth, Belfast BT12 6BJ, Antrim, North Ireland
[4] Vanderbilt Univ, Dept Med, Sch Med, Vanderbilt Ingram Canc Ctr,Vanderbilt Epidemiol C, Nashville, TN 37203 USA
关键词:
Diets;
Inflammation;
Reflux oesophagitis;
Barrett's oesophagus;
Oesophageal adenocarcinoma;
NONSTEROIDAL ANTIINFLAMMATORY DRUGS;
FOOD-CONSUMPTION SURVEY;
COLORECTAL-CANCER;
ASSOCIATION;
METAPLASIA;
SEQUENCE;
PATHWAY;
DESIGN;
FIBER;
D O I:
10.1017/S0007114517001131
中图分类号:
R15 [营养卫生、食品卫生];
TS201 [基础科学];
学科分类号:
100403 ;
摘要:
The dietary inflammatory index (DIITM) is a novel composite score based on a range of nutrients and foods known to be associated with inflammation. DII scores have been linked to the risk of a number of cancers, including oesophageal squamous cell cancer and oesophageal adenocarcinoma (OAC). Given that OAC stems from acid reflux and that the oesophageal epithelium undergoes a metaplasia-dysplasia transition from the resulting inflammation, it is plausible that a high DII score (indicating a pro-inflammatory diet) may exacerbate risk of OAC and its precursor conditions. The aim of this analytical study was to explore the association between energy-adjusted dietary inflammatory index (E-DIITM) in relation to risk of reflux oesophagitis, Barrett's oesophagus and OAC. Between 2002 and 2005, reflux oesophagitis (n 219), Barrett's oesophagus (n 220) and OAC (n 224) patients, and population-based controls (n 256), were recruited to the Factors influencing the Barrett's Adenocarcinoma Relationship study in Northern Ireland and the Republic of Ireland. E-DII scores were derived from a 101-item FFQ. Unconditional logistic regression analysis was applied to determine odds of oesophageal lesions according to E-DII intakes, adjusting for potential confounders. High E-DII scores were associated with borderline increase in odds of reflux oesophagitis (OR 1.87; 95% CI 0.93, 3.73), and significantly increased odds of Barrett's oesophagus (OR 2.05; 95% CI 1.22, 3.47), and OAC (OR 2.29; 95% CI 1.32, 3.96), when comparing the highest with the lowest tertiles of E-DII scores. In conclusion, a pro-inflammatory diet may exacerbate the risk of the inflammationmetaplasia-adenocarcinoma pathway in oesophageal carcinogenesis.
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页码:1323 / 1331
页数:9
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