Dietary inflammatory index and risk of reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma: a population-based case-control study

被引:17
|
作者
Shivappa, Nitin [1 ,2 ]
Hebert, James R. [1 ,2 ]
Anderson, Lesley A. [3 ]
Shrubsole, Martha J. [4 ]
Murray, Liam J. [3 ]
Getty, Lauren B. [3 ]
Coleman, Helen G. [3 ]
机构
[1] Univ South Carolina, Canc Prevent & Control Program, Dept Epidemiol & Biostat, Arnold Sch Publ Hlth, Columbia, SC 29208 USA
[2] Connecting Hlth Innovat LLC, Columbia, SC 29201 USA
[3] Queens Univ Belfast, Ctr Publ Hlth, Belfast BT12 6BJ, Antrim, North Ireland
[4] Vanderbilt Univ, Dept Med, Sch Med, Vanderbilt Ingram Canc Ctr,Vanderbilt Epidemiol C, Nashville, TN 37203 USA
关键词
Diets; Inflammation; Reflux oesophagitis; Barrett's oesophagus; Oesophageal adenocarcinoma; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; FOOD-CONSUMPTION SURVEY; COLORECTAL-CANCER; ASSOCIATION; METAPLASIA; SEQUENCE; PATHWAY; DESIGN; FIBER;
D O I
10.1017/S0007114517001131
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The dietary inflammatory index (DIITM) is a novel composite score based on a range of nutrients and foods known to be associated with inflammation. DII scores have been linked to the risk of a number of cancers, including oesophageal squamous cell cancer and oesophageal adenocarcinoma (OAC). Given that OAC stems from acid reflux and that the oesophageal epithelium undergoes a metaplasia-dysplasia transition from the resulting inflammation, it is plausible that a high DII score (indicating a pro-inflammatory diet) may exacerbate risk of OAC and its precursor conditions. The aim of this analytical study was to explore the association between energy-adjusted dietary inflammatory index (E-DIITM) in relation to risk of reflux oesophagitis, Barrett's oesophagus and OAC. Between 2002 and 2005, reflux oesophagitis (n 219), Barrett's oesophagus (n 220) and OAC (n 224) patients, and population-based controls (n 256), were recruited to the Factors influencing the Barrett's Adenocarcinoma Relationship study in Northern Ireland and the Republic of Ireland. E-DII scores were derived from a 101-item FFQ. Unconditional logistic regression analysis was applied to determine odds of oesophageal lesions according to E-DII intakes, adjusting for potential confounders. High E-DII scores were associated with borderline increase in odds of reflux oesophagitis (OR 1.87; 95% CI 0.93, 3.73), and significantly increased odds of Barrett's oesophagus (OR 2.05; 95% CI 1.22, 3.47), and OAC (OR 2.29; 95% CI 1.32, 3.96), when comparing the highest with the lowest tertiles of E-DII scores. In conclusion, a pro-inflammatory diet may exacerbate the risk of the inflammationmetaplasia-adenocarcinoma pathway in oesophageal carcinogenesis.
引用
收藏
页码:1323 / 1331
页数:9
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