Psychosocial factors and their association with reflux oesophagitis,Barrett's oesophagus and oesophageal adenocarcinoma

被引:3
|
作者
Paul Denver [1 ]
Michael Donnelly [1 ]
Liam J Murray [1 ]
Lesley A Anderson [1 ]
机构
[1] Centre for Public Health,Queen’s University Belfast,Belfast BT12 6BJ,Northern Ireland,United Kingdom
关键词
Reflux oesophagitis; Barrett’s oesophagus; Oesophageal adenocarcinoma; Adjustment; Psychological; Psychosocial factors;
D O I
暂无
中图分类号
R735.1 [食管肿瘤]; R571 [食管疾病];
学科分类号
1002 ; 100201 ; 100214 ;
摘要
AIM:To investigate the role of psychological characteristics as risk factors for oesophageal adenocarcinoma(OAC),as well as the reflux-mediated precursor pathway.METHODS:An all-Ireland population-based case-control study recruited 230 reflux oesophagitis(RO),224 Barrett’s oesophagus(BO) and 227 OAC patients and 260 controls.Each case/control group completed measures of stress,depression,self-efficacy,self-esteem,repression and social support.A comparative analysis was undertaken using polytomous logistic regression adjusted for potential confounders.RESULTS:Compared to controls,OAC patients were almost half as likely to report high stress levels over their lifetime(P = 0.010,OR 0.51;95%CI:0.29-0.90)and 36% less likely to report having experienced depression(OR 0.64;95%CI:0.42-0.98).RO patients reported significantly higher stress than controls particularly during middle-and senior-years(P for trends < 0.001).RO patients were 37% less likely to report having been highly emotionally repressed(OR 0.63;95%CI:0.41-0.95).All case groups(OAC,RO and BO) were more likely than controls to report having had substantial amounts of social support(OR 2.84;95%CI:1.63-4.97;OR 1.97;95%CI:1.13-3.44 and OR 1.83;95%CI:1.03-3.24,respectively).CONCLUSION:The improved psychological profile of OAC patients may be explained by response shift.The role of psychological factors in the development of OAC requires further investigation.
引用
收藏
页码:1770 / 1777
页数:8
相关论文
共 50 条
  • [1] Psychosocial factors and their association with reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma
    Denver, Paul
    Donnelly, Michael
    Murray, Liam J.
    Anderson, Lesley A.
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2013, 19 (11) : 1770 - 1777
  • [2] The path(ology) from reflux oesophagitis to Barrett oesophagus to oesophageal adenocarcinoma
    Salimian, Kevan J.
    Birkness-Gartman, Jacqueline
    Waters, Kevin M.
    [J]. PATHOLOGY, 2022, 54 (02) : 147 - 156
  • [3] Helicobacter pylori and Cag A status in oesophageal adenocarcinoma, Barrett's oesophagus, and reflux oesophagitis
    Anderson, LA
    Johnston, BT
    Watson, RGP
    Murphy, SJ
    Bamford, K
    Ghazy, A
    Ferguson, H
    Comber, H
    McGuigan, J
    Reynolds, JV
    Murray, LJ
    [J]. GUT, 2006, 55 : A107 - A107
  • [4] Risk of Barrett's oesophagus, oesophageal adenocarcinoma and reflux oesophagitis and the use of nitrates and asthma medications
    Ladanchuk, Todd C.
    Johnston, Brian T.
    Murray, Liam J.
    Anderson, Lesley A.
    [J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2010, 45 (12) : 1397 - 1403
  • [5] DIETARY MAGNESIUM, CALCIUM: MAGNESIUM RATIO AND RISK OF REFLUX OESOPHAGITIS, BARRETT'S OESOPHAGUS AND OESOPHAGEAL ADENOCARCINOMA
    Dai, Q.
    Cantwell, M. M.
    Murray, L. J.
    Zheng, W.
    Anderson, L. A.
    Coleman, H. G.
    [J]. GUT, 2015, 64 : A291 - A291
  • [6] Polymorphisms in DNA repair genes and their associations with risk of reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma
    Ferguson, H. R.
    Ferguson, H. R.
    Murray, L. J.
    Johnston, B. T.
    Anderson, L. A.
    Murphy, S. J.
    Watson, P.
    McGuigan, J.
    Reynolds, J. V.
    Comber, H.
    Wild, C. P.
    Hardie, L. J.
    [J]. GUT, 2007, 56 : A69 - A69
  • [7] Oesophagitis and Barrett's oesophagus - Are they related to the pattern of gastro-oesophageal reflux?
    Jalal, PK
    Dwarakanath, AD
    Tanner, AR
    [J]. GASTROENTEROLOGY, 2000, 118 (04) : A1252 - A1252
  • [8] Oesophageal acid exposure:: higher in Barrett's oesophagus than in reflux oesophagitis
    Salminen, JT
    Tuominen, JA
    Rämö, OJ
    Färkkilä, MA
    Salo, JA
    [J]. ANNALS OF MEDICINE, 1999, 31 (01) : 46 - 50
  • [9] Role of gastric atrophy in mediating negative association between Helicobacter pylori infection and reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma
    McColl, Kenneth E. L.
    Watabe, Hirotsugu
    Derakhshan, Mohammad H.
    [J]. GUT, 2008, 57 (06) : 721 - 723
  • [10] Multivariate analysis of the association of acid and duodeno-gastro-oesophageal reflux exposure with the presence of oesophagitis, the severity of oesophagitis and Barrett's oesophagus
    Koek, G. H.
    Sifrim, D.
    Lerut, T.
    Janssens, J.
    Tack, J.
    [J]. GUT, 2008, 57 (08) : 1056 - 1064