共 50 条
Psychosocial factors and their association with reflux oesophagitis,Barrett's oesophagus and oesophageal adenocarcinoma
被引:3
|作者:
Paul Denver
[1
]
Michael Donnelly
[1
]
Liam J Murray
[1
]
Lesley A Anderson
[1
]
机构:
[1] Centre for Public Health,Queen’s University Belfast,Belfast BT12 6BJ,Northern Ireland,United Kingdom
关键词:
Reflux oesophagitis;
Barrett’s oesophagus;
Oesophageal adenocarcinoma;
Adjustment;
Psychological;
Psychosocial factors;
D O I:
暂无
中图分类号:
R735.1 [食管肿瘤];
R571 [食管疾病];
学科分类号:
1002 ;
100201 ;
100214 ;
摘要:
AIM:To investigate the role of psychological characteristics as risk factors for oesophageal adenocarcinoma(OAC),as well as the reflux-mediated precursor pathway.METHODS:An all-Ireland population-based case-control study recruited 230 reflux oesophagitis(RO),224 Barrett’s oesophagus(BO) and 227 OAC patients and 260 controls.Each case/control group completed measures of stress,depression,self-efficacy,self-esteem,repression and social support.A comparative analysis was undertaken using polytomous logistic regression adjusted for potential confounders.RESULTS:Compared to controls,OAC patients were almost half as likely to report high stress levels over their lifetime(P = 0.010,OR 0.51;95%CI:0.29-0.90)and 36% less likely to report having experienced depression(OR 0.64;95%CI:0.42-0.98).RO patients reported significantly higher stress than controls particularly during middle-and senior-years(P for trends < 0.001).RO patients were 37% less likely to report having been highly emotionally repressed(OR 0.63;95%CI:0.41-0.95).All case groups(OAC,RO and BO) were more likely than controls to report having had substantial amounts of social support(OR 2.84;95%CI:1.63-4.97;OR 1.97;95%CI:1.13-3.44 and OR 1.83;95%CI:1.03-3.24,respectively).CONCLUSION:The improved psychological profile of OAC patients may be explained by response shift.The role of psychological factors in the development of OAC requires further investigation.
引用
收藏
页码:1770 / 1777
页数:8
相关论文