Co-expression of AFAP1-AS1 and PD-1 predicts poor prognosis in nasopharyngeal carcinoma

被引：118

作者：

Tang, Yanyan ^{[1
,2
,3
]}

He, Yi ^{[2
,4
,5
]}

Shi, Lei ^{[6
]}

Yang, Liting ^{[2
]}

Wang, Jinpeng ^{[2
]}

Lian, Yu ^{[2
]}

Fan, Chunmei ^{[2
]}

Zhang, Ping ^{[7
]}

Guo, Can ^{[2
]}

Zhang, Shanshan ^{[1
]}

Gong, Zhaojian ^{[2
,6
]}

Li, Xiayu ^{[3
]}

Xiong, Fang ^{[1
]}

Li, Xiaoling ^{[1
,2
,3
]}

Li, Yong ^{[2
,8
]}

Li, Guiyuan ^{[1
,2
,3
]}

Xiong, Wei ^{[1
,2
,3
]}

Zeng, Zhaoyang ^{[1
,2
,3
]}

机构：

[1] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Carcinogenesis, Changsha, Hunan, Peoples R China

[2] Cent S Univ, Canc Res Inst, Chinese Minist Educ, Key Lab Carcinogenesis & Canc Invas, Changsha, Hunan, Peoples R China

[3] Cent S Univ, Xiangya Hosp 3, Dis Genome Res Ctr, Key Lab Nonresolving Inflammat & Canc, Changsha, Hunan, Peoples R China

[4] Cent S Univ, Hunan Canc Hosp, Hunan Key Lab Translat Radiat Oncol, Changsha, Hunan, Peoples R China

[5] Cent S Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha, Hunan, Peoples R China

[6] Cent S Univ, Xiangya Hosp 2, Dept Pathol, Changsha, Hunan, Peoples R China

[7] Cent S Univ, Sch Informat Sci & Engn, Changsha, Hunan, Peoples R China

[8] Cleveland Clin, Dept Canc Biol, Lerner Res Inst, Cleveland, OH 44106 USA

来源：

ONCOTARGET | 2017年 / 8卷 / 24期

基金：

中国国家自然科学基金;

关键词：

long non-coding RNA; AFAP1-AS1; programmed death 1 (PD-1); prognosis; nasopharyngeal carcinoma (NPC); LONG NONCODING RNAS; EPITHELIAL-MESENCHYMAL TRANSITION; RENAL-CELL CARCINOMA; CD8; T-CELLS; GENE-EXPRESSION; IMMUNE EVASION; CANCER-CELLS; IMMUNOGLOBULIN EXPRESSION; SUSCEPTIBILITY LOCUS; CHROMOSOME; 3P21;

D O I：

10.18632/oncotarget.16545

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nasopharyngeal carcinoma (NPC) carries a high potential for metastasis and immune escape, with a great risk of relapse after primary treatment. Through analysis of whole genome expression profiling data in NPC samples, we found that the expression of a long non-coding RNA (lncRNA), actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1), is significantly correlated with the immune escape marker programmed death 1 (PD-1). We therefore assessed the expression of AFAP1-AS1 and PD-1 in a cohort of 96 paraffin-embedded NPC samples and confirmed that AFAP1-AS1 and PD-1 are co-expressed in infiltrating lymphocytes in NPC tissue. Moreover, patients with high expression of AFAP1-AS1 or PD-1 in infiltrating lymphocytes were more prone to distant metastasis, and NPC patients with positive expression of both AFAP1-AS1 and PD-1 had the poorest prognosis. This study suggests that AFAP1-AS1 and PD-1 may be potential therapeutic targets in NPC and that patients with co-expression of AFAP1-AS1 and PD-1 may be ideal candidates for future clinical trials of anti-PD-1 immune therapy.

引用

页码：39001 / 39011

页数：11

共 50 条

[31] PD-1 expression by tumor infiltrating lymphocytes is associated with poor prognosis in renal cell carcinoma patients
Thompson, RH
Dong, HD
Lohse, CM
Cheville, JC
Kwon, ED
[J]. JOURNAL OF UROLOGY, 2006, 175 (04): : 126 - 126
[32] Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and a poor prognosis in oral squamous cell carcinoma
Maruse, Y.
Kawano, S.
Jinno, T.
Matsubara, R.
Goto, Y.
Kaneko, N.
Sakamoto, T.
Hashiguchi, Y.
Moriyama, M.
Toyoshima, T.
Kitamura, R.
Tanaka, H.
Oobu, K.
Kiyoshima, T.
Nakamura, S.
[J]. INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2018, 47 (07) : 836 - 845
[33] Long noncoding RNA AFAP1-AS1 predicts a poor prognosis and regulates non–small cell lung cancer cell proliferation by epigenetically repressing p21 expression
Dandan Yin
Xiyi Lu
Jun Su
Xuezhi He
Wei De
Jinsong Yang
Wei Li
Liang Han
Erbao Zhang
[J]. Molecular Cancer, 17
[34] Co-expression of PD-L1 and HIF-1α predicts poor prognosis in Patients with Non-small Cell Lung Cancer after surgery
Zheng, Hongmei
Ning, Yue
Zhan, Yuting
Liu, Sile
Yang, Yang
Wen, Qiuyuan
Fan, Songqing
[J]. JOURNAL OF CANCER, 2021, 12 (07): : 2065 - 2072
[35] High PD-L1 Expression Predicts Metastasis in Nasopharyngeal Carcinoma
Li, X.
Jiang, Y.
Zhao, S.
Zhang, H.
Peng, X.
Ai, P.
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2018, 102 (03): : E331 - E331
[36] High expression of sphingosine kinase 1 is associated with poor prognosis in nasopharyngeal carcinoma
Li, Wenhua
Tian, Zhiqiang
Qin, Hong
Li, Ni
Zhou, Xiaoqing
Li, Jian
Ni, Bing
Ruan, Zhihua
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 460 (02) : 341 - 347
[37] The up-regulation of long non-coding RNA AFAP1-AS1 is associated with the poor prognosis of NSCLC patients
Deng, Jun
Liang, Yujia
Liu, Chunfeng
He, Shengdong
Wang, Songping
[J]. BIOMEDICINE & PHARMACOTHERAPY, 2015, 75 : 8 - 11
[38] PD-1 AND PD-L1 EXPRESSION ON THE PROGNOSIS OF OVARIAN CANCER
Li, R. P.
Li, W. Y.
Guo, Y. Z.
[J]. JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2019, 33 (04): : 1161 - 1166
[39] Long noncoding RNA AFAP1-AS1 predicts a poor prognosis and regulates non-small cell lung cancer cell proliferation by epigenetically repressing p21 expression
Yin, Dandan
Lu, Xiyi
Su, Jun
He, Xuezhi
De, Wei
Yang, Jinsong
Li, Wei
Han, Liang
Zhang, Erbao
[J]. MOLECULAR CANCER, 2018, 17
[40] High expression of AFAP1-AS1 is associated with poor survival and short-term recurrence in pancreatic ductal adenocarcinoma
Yibiao Ye
Jie Chen
Yu Zhou
Zhiqiang Fu
Quanbo Zhou
YingXue Wang
Wenchao Gao
ShangYou Zheng
Xiaohui Zhao
Tao Chen
Rufu Chen
[J]. Journal of Translational Medicine, 13

← 1 2 3 4 5 →