Epstein- Barr virus DNA in serum as an early prognostic marker in children and adolescents with Hodgkin lymphoma

被引：29

作者：

Welch, Jennifer J. G. ^{[1
]}

Schwartz, Cindy L. ^{[2
]}

Higman, Meghan ^{[3
]}

Chen, Lu ^{[4
]}

Buxton, Allen ^{[4
]}

Kanakry, Jennifer A. ^{[5
]}

Kahwash, Samir B. ^{[6
]}

Hutchison, Robert E. ^{[7
]}

Friedman, Debra L. ^{[8
]}

Ambinder, Richard F. ^{[9
]}

机构：

[1] Brown Univ, Alpert Med Sch, Hasbro Childrens Hosp, Providence, RI 02912 USA

[2] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[3] Roswell Pk Canc Inst, UBMD Pediat, Buffalo, NY 14263 USA

[4] Childrens Oncol Grp, Monrovia, CA USA

[5] NIH, Expt Transplantat & Immunol Branch, Bldg 10, Bethesda, MD 20892 USA

[6] Nationwide Childrens Hosp, Columbus, OH USA

[7] SUNY Upstate Med Univ, Dept Pathol, Syracuse, NY 13210 USA

[8] Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[9] Johns Hopkins Sch Med, Dept Oncol, Baltimore, MD USA

来源：

BLOOD ADVANCES | 2017年 / 1卷 / 11期

基金：

美国国家卫生研究院;

关键词：

EBV DNA; PLASMA; PREDICTS;

D O I：

10.1182/bloodadvances.2016002618

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Assay of cell-free DNA in blood offers an approach to assessment of tumor DNA. We sought to determine whether Epstein-Barr virus (EBV) DNA in cell-free blood is also a good surrogate for the presence of tumor DNA in children with Hodgkin lymphoma, as it is in adults, and whether it correlates with pediatric outcomes. Pediatric patients enrolled in a Children's Oncology Group trial (AHOD0031) were studied at baseline and at 8 days after the initiation of treatment. At baseline, EBV DNA in cell-free blood correlated with the presence of EBV in tumor, and EBV DNA 8 days after the initiation of therapy predicted inferior event-free survival. EBV DNA in cell-free blood warrants further investigation as a marker of inadequate tumor response in Hodgkin lymphoma.

引用

页码：681 / 684

页数：4

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