Epstein- Barr virus DNA in serum as an early prognostic marker in children and adolescents with Hodgkin lymphoma

被引：29
|
作者：
Welch, Jennifer J. G. [1 ]
Schwartz, Cindy L. [2 ]
Higman, Meghan [3 ]
Chen, Lu [4 ]
Buxton, Allen [4 ]
Kanakry, Jennifer A. [5 ]
Kahwash, Samir B. [6 ]
Hutchison, Robert E. [7 ]
Friedman, Debra L. [8 ]
Ambinder, Richard F. [9 ]
机构：
[1] Brown Univ, Alpert Med Sch, Hasbro Childrens Hosp, Providence, RI 02912 USA
[2] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[3] Roswell Pk Canc Inst, UBMD Pediat, Buffalo, NY 14263 USA
[4] Childrens Oncol Grp, Monrovia, CA USA
[5] NIH, Expt Transplantat & Immunol Branch, Bldg 10, Bethesda, MD 20892 USA
[6] Nationwide Childrens Hosp, Columbus, OH USA
[7] SUNY Upstate Med Univ, Dept Pathol, Syracuse, NY 13210 USA
[8] Vanderbilt Ingram Canc Ctr, Nashville, TN USA
[9] Johns Hopkins Sch Med, Dept Oncol, Baltimore, MD USA
来源：
BLOOD ADVANCES | 2017年 / 1卷 / 11期
基金：
美国国家卫生研究院;
关键词：
EBV DNA; PLASMA; PREDICTS;
D O I：
10.1182/bloodadvances.2016002618
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Assay of cell-free DNA in blood offers an approach to assessment of tumor DNA. We sought to determine whether Epstein-Barr virus (EBV) DNA in cell-free blood is also a good surrogate for the presence of tumor DNA in children with Hodgkin lymphoma, as it is in adults, and whether it correlates with pediatric outcomes. Pediatric patients enrolled in a Children's Oncology Group trial (AHOD0031) were studied at baseline and at 8 days after the initiation of treatment. At baseline, EBV DNA in cell-free blood correlated with the presence of EBV in tumor, and EBV DNA 8 days after the initiation of therapy predicted inferior event-free survival. EBV DNA in cell-free blood warrants further investigation as a marker of inadequate tumor response in Hodgkin lymphoma.
引用
收藏
页码：681 / 684
页数：4
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