The correlation between CpG methylation and protein expression of P16 in oral squamous cell carcinomas

被引：0
|
作者：
Huang, MJ
Yeh, KT
Shih, HC
Wang, YF
Lin, TH
Chang, JY
Shih, MC
Chang, JG
机构：
[1] China Med Coll Hosp, Dept Mol Med, Taichung, Taiwan
[2] Mackay Mem Hosp, Dept Internal Med, Hematooncol Sect, Taipei, Taiwan
[3] Changhua Christian Hosp, Dept Pathol, Changhua, Taiwan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2002年 / 10卷 / 05期
关键词：
CpG methylation; protein expression; P16; oral SCC;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We examined the P16 expression by immunohistochemical stain and detected the methylation by methylation specific polymerase chain reaction (MSP) in 48 primary oral squamous cell carcinoma (SCC) tissues. The results showed that 20/48 (41.7%) of cancerous tissues had CpG methylation around the promoter region, but 8/48 (17%) of the nearby non-carcerous tissues also had CpG methylation, around the promoter region. The results from immunohistochemical studies showed that reduced and heterogeneous expression of P16 were found in the tissues, which had CpG methylation around the promoter region. In conclusion, the methylation of P16 in oral SCC occurs in pre-cancerous and cancerous stage, which results in decreasing or abolishing the P16 expression, which is heterogeneous in the cancer cells.
引用
收藏
页码：551 / 554
页数：4
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