Mating-type locus of Cryptococcus neoformans:: a step in the evolution of sex chromosomes

被引：189

作者：

Lengeler, KB ^{[1
]}

Fox, DS ^{[1
]}

Fraser, JA ^{[1
]}

Allen, A ^{[1
]}

Forrester, K ^{[1
]}

Dietrich, FS ^{[1
]}

Heitman, J ^{[1
]}

机构：

[1] Duke Univ, Dept Mol Genet & Microbiol, Howard Hughes Med Inst, Durham, NC 27710 USA

来源：

EUKARYOTIC CELL | 2002年 / 1卷 / 05期

关键词：

D O I：

10.1128/EC.1.5.704-718.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The sexual development and virulence of the fungal pathogen Cryptococcus neoformans is controlled by a bipolar mating system determined by a single locus that exists in two alleles, alpha and a. The alpha and a mating-type alleles from two divergent varieties were cloned and sequenced. The C. neoformans mating-type locus is unique, spans >100 kb, and contains more than 20 genes. MAT-encoded products include homologs of regulators of sexual development in other fungi, pheromone and pheromone receptors, divergent components of a MAP kinase cascade, and other proteins with no obvious function in mating. The a and a alleles of the mating-type locus have extensively rearranged during evolution and strain divergence but are stable during genetic crosses and in the population. The C. neoformans mating-type locus is strikingly different from the other known fungal mating-type loci, sharing features with the self-incompatibility systems and sex chromosomes of algae, plants, and animals. Our study establishes a new paradigm for mating-type loci in fungi with implications for the evolution of cell identity and self/nonself recognition.

引用

页码：704 / 718

页数：15

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