A high-content imaging platform for quantitative assessment of immunogenic tumor cell killing and T-cell proliferation in 3D tumoroids of fresh patient tumor samples

被引:0
|
作者
Mediavilla-Varela, Melanie [1 ]
Agrawal, Vijayendra [1 ]
Page, Melba Marie [1 ]
Kreahling, Jenny [1 ]
Altiok, Soner [1 ]
机构
[1] Nilogen Oncosyst, Tampa, FL USA
关键词
D O I
10.1158/1538-7445.SABCS18-34
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
34
引用
收藏
页数:2
相关论文
共 47 条
  • [1] The importance of intact tumor immune microenvironment in unpropagated 3D fresh patient tumoroids in immuno-oncology drug testing for immunogenic tumor cell death and T-cell activation
    Agrawal, Vijayendra
    Mediavilla-Varela, Melanie
    Page, Melba Marie
    Kreahling, Jenny
    Altiok, Soner
    [J]. CANCER RESEARCH, 2019, 79 (13)
  • [2] High-content imaging assays on a miniaturized 3D cell culture platform
    Joshi, Pranav
    Datar, Akshata
    Yu, Kyeong-Nam
    Kang, Soo-Yeon
    Lee, Moo-Yeal
    [J]. TOXICOLOGY IN VITRO, 2018, 50 : 147 - 159
  • [3] Assessment of immunotherapeutic efficacy of entinostat by using the 3d-explore ex vivo platform utilizing tumoroids of fresh patient tumor samples with intact tumor microenvironment
    Kodumudi, Krithika Nandakumar
    Bunch, Brittany
    Ehrhart, Jared
    Weitzman, Matt
    MacIntosh, Olivia
    Sussman, Kelly
    Altiok, Soner
    [J]. CANCER RESEARCH, 2022, 82 (12)
  • [4] DETERMINING THE EFFICACY OF ADCC BY THE 3D-EX EX VIVO PLATFORM UTILIZING TUMOROIDS OF FRESH PATIENT TUMOR SAMPLES WITH INTACT TUMOR MICROENVIRONMENT
    Kreahling, Jenny
    Ehrhart, Jared
    Iwanowycz, Stephen
    Pabon, Mibel
    Pastoor, Tina
    Altiok, Soner
    [J]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 : A336 - A336
  • [5] An Optimized High-Content Imaging Workflow for 3D Spheroid Cell Models
    Wardwell-Swanson, Judith
    Tully, Arvonn
    Yavas, Özlem
    Suzuki, Mahomi
    Frey, Olivier
    [J]. Genetic Engineering and Biotechnology News, 2021, 41 (06): : 72 - 74
  • [6] Translation of a Tumor Microenvironment Mimicking 3D Tumor Growth Co-culture Assay Platform to High-Content Screening
    Krausz, Eberhard
    de Hoogt, Ronald
    Gustin, Emmanuel
    Cornelissen, Frans
    Grand-Perret, Thierry
    Janssen, Lut
    Vloemans, Nele
    Wuyts, Dirk
    Frans, Sandy
    Axel, Amy
    Peeters, Pieter Johan
    Hall, Brett
    Cik, Miroslav
    [J]. JOURNAL OF BIOMOLECULAR SCREENING, 2013, 18 (01) : 54 - 66
  • [7] 3D-EXplore platform of fresh patient tumoroids with intact TME allows assessment of the efficacy of drugs targeting the tumor stroma on ex vivo tumor immunotherapy
    Currlin, Seth
    Ruedlinger, Brittney
    Camacho, Sharon
    Rivera, Angie
    D'Andrea, Jasmin
    Ehrhart, Jared
    Altiok, Soner
    [J]. CANCER RESEARCH, 2023, 83 (07)
  • [8] An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models
    Celli, Jonathan P.
    Rizvi, Imran
    Blanden, Adam R.
    Massodi, Iqbal
    Glidden, Michael D.
    Pogue, Brian W.
    Hasan, Tayyaba
    [J]. SCIENTIFIC REPORTS, 2014, 4
  • [9] 3D tumor spheroid microarray for high-throughput, high-content natural killer cell-mediated cytotoxicity
    Gopal, Sneha
    Kwon, Seok-Joon
    Ku, Bosung
    Lee, Dong Woo
    Kim, Jungeun
    Dordick, Jonathan S.
    [J]. COMMUNICATIONS BIOLOGY, 2021, 4 (01)
  • [10] An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models
    Jonathan P. Celli
    Imran Rizvi
    Adam R. Blanden
    Iqbal Massodi
    Michael D. Glidden
    Brian W. Pogue
    Tayyaba Hasan
    [J]. Scientific Reports, 4