The importance of intact tumor immune microenvironment in unpropagated 3D fresh patient tumoroids in immuno-oncology drug testing for immunogenic tumor cell death and T-cell activation

被引:0
|
作者
Agrawal, Vijayendra [1 ]
Mediavilla-Varela, Melanie [1 ]
Page, Melba Marie [1 ]
Kreahling, Jenny [1 ]
Altiok, Soner [1 ]
机构
[1] Nilogen Oncosyst, Tampa, FL USA
关键词
D O I
10.1158/1538-7445.SABCS18-42
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
42
引用
收藏
页数:2
相关论文
共 13 条
  • [1] A novel 3D ex vivo platform of fresh patient tumor tissue with intact tumor microenvironment for immuno-oncology drug development and biomarker discovery
    Mediavilla-Varela, Melanie
    Page, Melba Marie
    Kreahling, Jenny
    Antonia, Scott
    Altiok, Soner
    [J]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
  • [2] A high-content imaging platform for quantitative assessment of immunogenic tumor cell killing and T-cell proliferation in 3D tumoroids of fresh patient tumor samples
    Mediavilla-Varela, Melanie
    Agrawal, Vijayendra
    Page, Melba Marie
    Kreahling, Jenny
    Altiok, Soner
    [J]. CANCER RESEARCH, 2019, 79 (13)
  • [3] 3D in vitro system for immuno-oncology: Real-time imaging of drug delivery, tumoroids, and immune cell activity
    McGhee, Eric O.
    McGhee, Alex J.
    Hood, Derek L.
    Van Meter, Kylie E.
    Uruena, Juan M.
    Mitchell, Duane A.
    Flores, Catherine T.
    Ghivizzani, Steven C.
    Gibbs, C. Parker
    Levings, Padriac P.
    Anderson, Colin J.
    Sawyer, W. Gregory
    [J]. CANCER RESEARCH, 2019, 79 (13)
  • [4] Biology reconstructed: Testing immuno-oncology agents in tumor-specific 3D cell culture
    Kirshner, Julia
    Parikh, Mukti R.
    [J]. CANCER RESEARCH, 2020, 80 (16)
  • [5] A novel ex vivo 3D tumor organoid model of fresh patient tumors (3D-ACT) to assess efficacy of cellular therapy in immuno-oncology
    Agrawal, Vijayendra
    Pabon, Mibel
    Page, Melba Marie
    Kreahling, Jenny
    Altiok, Soner
    [J]. MOLECULAR CANCER THERAPEUTICS, 2019, 18 (12)
  • [6] Novel patient avatar platform for oncology drug testing using 3D ex vivo models derived from fresh patient tumor tissues
    Beztsinna, Nataliia
    Grillet, Fanny
    Meesters, Niels
    van der Meer, Donny
    Daszkiewicz, Lidia
    Yan, Kuan
    Spanjaard, Emma
    Vader, Willemijn
    Price, Leo
    [J]. MOLECULAR CANCER THERAPEUTICS, 2021, 20 (12)
  • [7] A patient-driven ex vivo 3D tumor organoid model to assess efficacy of tumor infiltrating T-cell adoptive cell therapy
    Kreahling, Jenny
    Pabon, Mibel
    Page, Melba
    Agrawal, Vijayendra
    Altiok, Soner
    [J]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [8] Leveraging artificial intelligence to advance immuno-oncology drug development using functional ex-vivo 3D-tumor organoid platforms of fresh patient tissue samples
    Kreahling, Jenny
    Santiago, Daniel
    Agrawal, Vijayendra
    Pabon, Mibel
    Altiok, Soner
    Page, Melba
    [J]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [9] An ex-vivo 3D tumoroid model of fresh patient tissue (3D-EXplore) to assess transcriptional and compositional changes of the immune landscape in intact tumor microenvironment using single-cell proteogenomics
    Waterman-Smith, Jonathan P.
    Ehrhart, Jared
    Bunch, Brittany
    Kodumudi, Krithika
    Weitzman, Matt
    MacIntosh, Olivia
    Sussman, Kelly
    Altiok, Soner
    [J]. CANCER RESEARCH, 2022, 82 (12)
  • [10] A Novel Hydrogel-Based 3D In Vitro Tumor Panel of 30 PDX Models Incorporates Tumor, Stromal and Immune Cell Compartments of the TME for the Screening of Oncology and Immuno-Therapies
    Xue, Bin
    Schueler, Julia
    Harrod, Christopher M.
    Lashuk, Kanstantsin
    Bomya, Zoji
    Hribar, Kolin C.
    [J]. CELLS, 2023, 12 (08)