Evaluating the use of pharmacological stress agents during single-photon emission computed tomography myocardial perfusion imaging tests after inadequate exercise stress test

被引:4
|
作者
Yang, Hongbo [1 ]
Faust, Elizabeth [1 ]
Gao, Emily [1 ]
Sethi, Sakshi [1 ]
Kitt, Therese M. [2 ]
Kristy, Rita M. [2 ]
Spalding, James R. [2 ]
Xu, Yanqing [2 ]
机构
[1] Anal Grp, Boston, MA USA
[2] Astellas Pharma Global Dev, Northbrook, IL 60062 USA
关键词
SPECT; MPI; Exercise testing;
D O I
10.1007/s12350-021-02546-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Past clinical trial findings suggest that the availability of regadenoson in a nuclear imaging center may affect real-world center practices related to the transition of patients from an inadequate exercise stress test (EST) to a pharmacological stress agent (PSA). Methods and Results This was a cross-sectional study using one-on-one telephone interviews with nuclear imaging center staff to facilitate survey development, followed by an online survey to evaluate patterns and processes around use of PSAs during single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) in patients with inadequate ESTs. Of the 50 participants, 35 (70%) used only regadenoson, 3 (6%) only adenosine, 3 (6%) regadenoson and adenosine, 7 (14%) regadenoson and dipyridamole, and 2 (4%) all 3 agents for converting patients from an inadequate EST to a PSA. Nearly all centers (94%) used protocols to guide conversions. Of 12 centers using > 1 PSA, 11 reported regadenoson to be the most preferred PSA. Total staff time required from PSA transition to post-test monitoring was shortest for regadenoson. Conclusions Compared to adenosine and dipyridamole, regadenoson is preferred by nuclear imaging center staff and associated with operational efficiencies after inadequate EST in real-world practice SPECT-MPI.
引用
收藏
页码:1788 / 1795
页数:8
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