Natural and Synthetic Sialylated Glycan Microarrays and Their Applications

被引：20
|
作者：
McQuillan, Alyssa M. [1 ]
Byrd-Leotis, Lauren [1 ,2 ]
Heimburg-Molinaro, Jamie [1 ]
Cummings, Richard D. [1 ]
机构：
[1] Harvard Med Sch, Dept Surg, Beth Israel Deaconess Med Ctr, Natl Ctr Funct Glyc, Boston, MA 02115 USA
[2] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA
来源：
FRONTIERS IN MOLECULAR BIOSCIENCES | 2019年 / 6卷
关键词：
sialylated glycans; glycan microarrays; synthetic glycans; natural glycans; glycan binding proteins; functional glycomics; Neu5Ac; Neu5Gc; SIALIC-ACID DIVERSITY; CHEMOENZYMATIC SYNTHESIS; RECOGNITION PROPERTIES; SHOTGUN GLYCOMICS; N-GLYCANS; BINDING; PROTEIN; SIALOSIDES; RECEPTOR; STRATEGY;
D O I：
10.3389/fmolb.2019.00088
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This focused chapter serves as a short survey of glycan microarrays that are available with sialylated glycans, including both defined and shotgun arrays, their generation, and their utility in studying differential binding interactions to sialylated compounds, highlighting N-glycolyl (Gc) modified sialylated compounds. A brief discussion of binding interactions by lectins, antibodies, and viruses, and their relevance that have been observed with sialylated glycan microarrays is presented, as well as a discussion of cross-comparisons of array platforms and efforts to centralize and standardize the glycan microarray data.
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页数：11
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