HEXABODY-CD27 ENHANCES T-CELL ACTIVATION, PROLIFERATION, CYTOKINE SECRETION AND CYTOTOXIC ACTIVITY INDEPENDENTLY OF FC GAMMA RECEPTOR-MEDIATED CROSSLINKING

被引:0
|
作者
Nurmberger, Kristina [2 ]
Imle, Andrea [2 ]
Toker, Aras [2 ]
Strumane, Kristin [1 ]
Fellermeier-Kopf, Sina [2 ]
Ioan-Facsinay, Andreea [1 ]
Muik, Alexander [2 ]
Diken, Mustafa [2 ]
Beurskens, Frank [1 ]
De Jong, Rob [1 ]
Kreiter, Sebastian [2 ]
Satijn, David [1 ]
Gieseke, Friederike [2 ]
Schuurman, Janine [1 ]
Ahmadi, Tahamtam
Tuereci, Oezlem [2 ]
Sasser, Kate [3 ]
Breij, Esther [1 ]
Sahin, Ugur [2 ]
Altinas, Isil [1 ]
机构
[1] Genmab BV, Utrecht, Netherlands
[2] BioNTech SE, Mainz, Germany
[3] Genmab US Inc, Plainsboro, NJ USA
关键词
D O I
10.1136/jitc-2022-SITC2022.1070
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1070
引用
收藏
页码:A1112 / A1112
页数:1
相关论文
共 29 条
  • [1] T-cell activation by recombinant receptors: CD28 costimulation is required for interleukin 2 secretion and receptor-mediated T-cell proliferation but does not affect receptor-mediated target cell lysis
    Hombach, A
    Sent, D
    Schneider, C
    Heuser, C
    Koch, D
    Pohl, C
    Seliger, B
    Abken, H
    CANCER RESEARCH, 2001, 61 (05) : 1976 - 1982
  • [2] T-CELL FC-GAMMA RECEPTOR-MEDIATED IMMUNOREGULATORY ABNORMALITIES IN RHEUMATOID-ARTHRITIS
    SAYEEDUDDIN, S
    ISHAQ, M
    MEDICAL SCIENCE RESEARCH, 1993, 21 (16): : 597 - 597
  • [3] Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner
    Seggewiss, R
    Loré, K
    Greiner, E
    Magnusson, MK
    Price, DA
    Douek, DC
    Dunbar, CE
    Wiestner, A
    BLOOD, 2005, 105 (06) : 2473 - 2479
  • [4] The therapeutic CD38 mAb daratumumab induces programmed cell death by Fc gamma receptor-mediated crosslinking
    Overdijk, M. B.
    Jansen, J. H. M.
    Nederend, M.
    van Bueren, J. J. Lammerts
    Groen, R. W. J.
    Parren, P. W. H. I.
    Leusen, J. H. W.
    Boross, P.
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2014, 44 : 34 - 34
  • [5] Cytotoxic response of human regulatory T cells upon T-cell receptor-mediated activation: a matter of purity
    S Koristka
    M Cartellieri
    C Arndt
    A Feldmann
    K Töpfer
    I Michalk
    A Temme
    G Ehninger
    M Bachmann
    Blood Cancer Journal, 2014, 4 : e199 - e199
  • [6] Cytotoxic response of human regulatory T cells upon T-cell receptor-mediated activation: a matter of purity
    Koristka, S.
    Cartellieri, M.
    Arndt, C.
    Feldmann, A.
    Toepfer, K.
    Michalk, I.
    Temme, A.
    Ehninger, G.
    Bachmann, M.
    BLOOD CANCER JOURNAL, 2014, 4 : e199 - e199
  • [7] T-CELL RECEPTOR-INDEPENDENT ACTIVATION OF CYTOLYTIC ACTIVITY OF CYTOTOXIC LYMPHOCYTES-T MEDIATED THROUGH CD44
    GOTE, L
    SETH, A
    NAGARKATTI, PS
    NAGARKATTI, M
    FASEB JOURNAL, 1991, 5 (05): : A994 - A994
  • [8] T-CELL TUMOR CURE BY T-CELL RECEPTOR-MEDIATED ACTIVATION REQUIRES THE DEVELOPMENT OF CD8-DEPENDENT HOST IMMUNITY
    BRIDGES, SH
    LONGO, DL
    JOURNAL OF IMMUNOLOGY, 1990, 144 (05): : 2010 - 2017
  • [9] CYTOSKELETAL FUNCTION IN CD8-CELL AND T-CELL RECEPTOR-MEDIATED INTERACTION OF CYTOTOXIC LYMPHOCYTES-T WITH CLASS-I PROTEIN
    OROURKE, AM
    APGAR, JR
    KANE, KP
    MARTZ, E
    MESCHER, MF
    JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (01): : 241 - 249
  • [10] CD28-MEDIATED COSTIMULATION IS NECESSARY FOR THE ACTIVATION OF T-CELL RECEPTOR-GAMMA-DELTA+ T-LYMPHOCYTES
    SPERLING, AI
    LINSLEY, PS
    BARRETT, TA
    BLUESTONE, JA
    JOURNAL OF IMMUNOLOGY, 1993, 151 (11): : 6043 - 6050