Induction of mixed allogeneic chimerism for leukemia

被引：2
|
作者：
Seledtsov, VI [1 ]
Seledtsova, GV [1 ]
Avdeev, EV [1 ]
Samarin, DM [1 ]
Kozlov, VA [1 ]
机构：
[1] INST CLIN IMMUNOL,DEPT EXPT IMMUNOL,NOVOSIBIRSK 630099,RUSSIA
来源：
LEUKEMIA RESEARCH | 1997年 / 21卷 / 10期
关键词：
graft-vs-leukemia effect; mixed allogeneic hematopoietic chimerism;
D O I：
10.1016/S0145-2126(97)00011-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hybrid (C56BL/6 x DBA) (BDF1; H-2(b)/H-2(d)) mice bearing the P815 leukemia (H-2(d)) were grafted with a (CBA x C57BL/6)F1 (CBF1; H-2(k)/H-2(b)) cell suspension, comprising bone marrow cells (BMC; 25 x 10(6)/mouse) and spleen cells (SC; 55 x 10(6)/mouse) on day -4, then treated with cyclophosphamide (200 mg/kg) on day -2 and finally grafted once more with CBF1 cells (25 x 10(6) BMC+7 x 10(6) SC) on day 0. Allogeneic cell graftings performed in this way induced durable mixed hematopoietic chimerism and significantly prolonged the survival of recipients, compared with that of leukemia-bearers grafted with syngeneic cells, The results obtained raise the possibility of using allogeneic hematopoietic tissue transplantation in combination with non-lethal cytoreductive therapy to induce a long-lasting graft-vs-leukemia effect. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：907 / 909
页数：3
相关论文
共 50 条
  • [31] Mixed T Lymphocyte Chimerism after Allogeneic Hematopoietic Transplantation Is Predictive for Relapse of Acute Myeloid Leukemia and Myelodysplastic Syndromes
    Lee, Hans C.
    Saliba, Rima M.
    Rondon, Gabriela
    Chen, Julianne
    Charafeddine, Yasmeen
    Medeiros, L. Jeffrey
    Alatrash, Gheath
    Andersson, Borje S.
    Popat, Uday
    Kebriaei, Partow
    Ciurea, Stefan
    Oran, Betul
    Shpall, Elizabeth
    Champlin, Richard
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2015, 21 (11) : 1948 - 1954
  • [32] LYMPHOHEMOPOIETIC AND STROMAL CHIMERISM AFTER ALLOGENEIC BMT FOR CHRONIC MYELOGENOUS LEUKEMIA
    SCHMITZ, N
    SCHMIDT, G
    SUTTORP, M
    JOHANNSON, W
    GASSMANN, W
    LOFFLER, H
    [J]. EXPERIMENTAL HEMATOLOGY, 1988, 16 (06) : 500 - 500
  • [33] Nonlethal conditioning for the induction of allogeneic chimerism and tolerance to islet allografts.
    Li, H
    Inverardi, L
    Molano, RD
    Pileggi, A
    Ricordi, C
    [J]. TRANSPLANTATION, 2003, 75 (07) : 966 - 970
  • [34] Mixed allogeneic chimerism to induce tolerance to solid organ and cellular grafts
    Exner, BG
    Acholonu, IN
    Bergheim, M
    Mueller, YM
    Ildstad, ST
    [J]. ACTA HAEMATOLOGICA, 1999, 101 (02) : 78 - 81
  • [35] MIXED CHIMERISM AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR LEUKEMIAS
    BERTHEAS, MF
    LAFAGE, M
    BLAISE, D
    STOPPA, AM
    VIENS, P
    MANNONI, P
    MARANINCHI, D
    [J]. BONE MARROW TRANSPLANTATION, 1990, 6 : 61 - 63
  • [36] MIXED ALLOGENEIC CHIMERISM AND RENAL-ALLOGRAFT TOLERANCE IN CYNOMOLGUS MONKEYS
    KAWAI, T
    COSIMI, AB
    COLVIN, RB
    POWELSON, J
    EASON, J
    KOZLOWSKI, T
    SYKES, M
    MONROY, R
    TANAKA, M
    SACHS, DH
    [J]. TRANSPLANTATION, 1995, 59 (02) : 256 - 262
  • [37] Mixed Chimerism and Secondary Engraftment Failure in Allogeneic Transplantation for Aplastic Anemia
    Kako, Shinichi
    Yamazaki, Hirohito
    Ohashi, Kazuteru
    Ozawa, Yukiyasu
    Ota, Shuichi
    Kanda, Yoshinobu
    Maeda, Tetsuo
    Kato, Jun
    Ishiyama, Ken
    Matsuoka, Ken-Ichi
    Miyamoto, Toshihiro
    Fukuda, Takahiro
    Ichinohe, Tatsuo
    Atsuta, Yoshiko
    Mori, Takehiko
    [J]. BLOOD, 2018, 132
  • [38] Evidence That the Innate Immune System Is Tolerized by Mixed Allogeneic Chimerism.
    Xu, Hong
    Zhu, Ziqiang
    Hussain, Lala R.
    Huang, Yiming
    Bozulic, Larry D.
    Yan, Jun
    Ildstad, Suzanne T.
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2009, 9 : 719 - 719
  • [39] Mixed chimerism and TREC values in immunodeficiency children undergoing allogeneic HCST
    Wysoczanska, B
    Dlubek, D
    Bogunia-Kubik, K
    Drabczak-Skrzypek, D
    Jaskula, E
    Kanska, K
    Kusnierz-Wolska, B
    Bernatowska, E
    Lange, A
    [J]. GENES AND IMMUNITY, 2005, 6 : S73 - S73
  • [40] Persistent mixed chimerism in plasma cells following allogeneic stem-cell transplantation (SCT) in patients with acute leukemia is a surrogate marker for leukemia relapse
    Shimoni, A
    Trakhtenbrot, L
    Ishoev, G
    Hardan, I
    Shem-Tov, N
    Rechavi, G
    Amariglio, N
    Nagler, A
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2006, 12 (02) : 53 - 53
12345