Iron-Catalyzed Triazole-Enabled C-H Activation with Bicyclopropylidenes

被引：13

作者：

Mo, Jiayu ^{[1
]}

Messinis, Antonis M. ^{[1
]}

Oliveira, Joao C. A. ^{[1
]}

Demeshko, Serhiy ^{[2
]}

Meyer, Franc ^{[2
,3
]}

Ackermann, Lutz ^{[1
,3
]}

机构：

[1] Georg August Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

[2] Georg August Univ Gottingen, Inst Anorgan Chem, D-37077 Gottingen, Germany

[3] Georg August Univ Gottingen, WISCh Wohler Res Inst Sustainable Chem, D-37077 Gottingen, Germany

来源：

ACS CATALYSIS | 2021年 / 11卷 / 03期

关键词：

iron; C-H C-C activation; C-F/C-H activation; BCP; mechanism; Mossbauer study;

D O I：

10.1021/acscatal.0c04748

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

C-H/C-C functionalizations with oxymethylated bicyclopropylidenes were accomplished with an iron catalyst under external oxidant-free conditions. The combination of the unique reactivity of bicyclopropylidenes with a robust iron(II) catalyst enabled C-C cleavages in a chemoselective fashion, which allows for the synthesis of isoquinolones, free isoquinolones, or bispiro-fused isoquinolones. Mechanistic studies provided strong support for the C-C cleavage via beta-C elimination. A rare monoselective C-F/C-H bond functionalization of trifluoromethylarene was also observed.

引用

页码：1053 / 1064

页数：12

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