Oxidative stress resistance and fitness-compensatory response in vancomycin-intermediate Staphylococcus aureus (VISA)

被引：2

作者：

Tan, Xin-Ee ^{[1
,3
]}

Neoh, Hui-min ^{[1
,2
]}

Cui, Longzhu ^{[3
]}

Hiramatsu, Keiichi ^{[2
]}

Jamal, Rahman ^{[1
]}

机构：

[1] Univ Kebangsaan Malaysia, UKM Med Mol Biol Inst UMBI, Bangi, Malaysia

[2] Juntendo Univ, Sch Med, Dept Bacteriol, Tokyo, Japan

[3] Jichi Med Univ, Sch Med, Dept Infect & Immun, Div Bacteriol, Shimotsuke, Tochigi, Japan

来源：

CANADIAN JOURNAL OF MICROBIOLOGY | 2019年 / 65卷 / 08期

关键词：

vancomycin-intermediate Staphylococcus aureus; oxidative stress; virulence; fitness cost; METHIONINE SULFOXIDE REDUCTASES; VIRULENCE; MODEL;

D O I：

10.1139/cjm-2019-0048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, vancomycin-intermediate Staphylococcus aureus (VISA) cells carrying vraS and (or) graR mutations were shown to be more resistant to oxidative stress. Caenorhabditis elegans infected with these strains in turn demonstrated lower survival. Altered regulation in oxidative stress response and virulence appear to be physiological adaptations associated with the VISA phenotype in the Mu50 lineage.

引用

页码：623 / 628

页数：6

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