High and Low WWOX Gene Expression Levels in Acute Myeloid Leukemia - a Real Time RT-PCR Study

被引：0
|
作者：
Elbossaty, Walaa F. [1 ]
Malak, Camelia A. A. [1 ]
Elghanam, Doaa [2 ]
机构：
[1] Damietta Univ, Fac Sci, Biochem Div, Dept Chem, Dumyat, Egypt
[2] Mansoura Univ, Mansoura, Egypt
来源：
CLINICAL LABORATORY | 2019年 / 65卷 / 09期
关键词：
AML; WWOX; tumor suppressor gene; hematological parameters; DFS; OS; QRT-PCR; TUMOR-SUPPRESSOR; CANCER; FRA16D; METHYLATION; HISTOTYPES; CARCINOMA; VARIES;
D O I：
10.7754/Clin.Lab.2019.190119
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background: Although expression of WWOX was extensively studied in different tumors, WWOX gene expression in acute myeloid leukemia is not well-known or recognized. Methods: Fifty control donors and fifty acute myeloid leukemia patients were enrolled in this research. The levels of WWOX gene in all participants were detected by RT-qPCR. Results: Levels of WWOX gene in the AML group were significantly lower as compared to the control group (0.27205 +/- 1.19812 vs. 10.501 +/- 9.0338, respectively, p < 0.001**). Conclusions: Decreased expression of WWOX gene ran parallel with acute myeloid leukemia regression.
引用
收藏
页码：1607 / 1613
页数：7
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