High and Low WWOX Gene Expression Levels in Acute Myeloid Leukemia - a Real Time RT-PCR Study

被引：0
|
作者：
Elbossaty, Walaa F. [1 ]
Malak, Camelia A. A. [1 ]
Elghanam, Doaa [2 ]
机构：
[1] Damietta Univ, Fac Sci, Biochem Div, Dept Chem, Dumyat, Egypt
[2] Mansoura Univ, Mansoura, Egypt
来源：
CLINICAL LABORATORY | 2019年 / 65卷 / 09期
关键词：
AML; WWOX; tumor suppressor gene; hematological parameters; DFS; OS; QRT-PCR; TUMOR-SUPPRESSOR; CANCER; FRA16D; METHYLATION; HISTOTYPES; CARCINOMA; VARIES;
D O I：
10.7754/Clin.Lab.2019.190119
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background: Although expression of WWOX was extensively studied in different tumors, WWOX gene expression in acute myeloid leukemia is not well-known or recognized. Methods: Fifty control donors and fifty acute myeloid leukemia patients were enrolled in this research. The levels of WWOX gene in all participants were detected by RT-qPCR. Results: Levels of WWOX gene in the AML group were significantly lower as compared to the control group (0.27205 +/- 1.19812 vs. 10.501 +/- 9.0338, respectively, p < 0.001**). Conclusions: Decreased expression of WWOX gene ran parallel with acute myeloid leukemia regression.
引用
收藏
页码：1607 / 1613
页数：7
相关论文
共 50 条
  • [1] WWOX expression in colorectal cancer-a real-time quantitative RT-PCR study
    Zelazowski, Maciej Jakub
    Pluciennik, Elzbieta
    Pasz-Walczak, Grazyna
    Potemski, Piotr
    Kordek, Radzislaw
    Bednarek, Andrzej Kazimierz
    TUMOR BIOLOGY, 2011, 32 (03) : 551 - 560
  • [2] hTERT mRNA levels by real-time RT-PCR in acute myelogenous leukemia
    Huh, HJ
    Huh, JW
    Yoo, ES
    Seong, CM
    Lee, M
    Hong, KS
    Chung, WS
    AMERICAN JOURNAL OF HEMATOLOGY, 2005, 79 (04) : 267 - 273
  • [3] The use of housekeeping genes for real time RT-PCR based quantification of fusion gene transcripts in acute myeloid leukemia
    Weisser, M
    Schoch, C
    Haferlach, T
    Hiddemann, W
    Schnittger, S
    BLOOD, 2002, 100 (11) : 233B - 233B
  • [4] The correlation analysis of WWOX expression and cancer related genes in neuroblastoma- a real time RT-PCR study
    Nowakowska, Magdalena
    Pluciennik, Elzbieta
    Wujcicka, Wioletta I.
    Sitkiewicz, Anna
    Kazanowska, Bernarda
    Zielinska, Elzbieta
    Bednarek, Andrzej K.
    ACTA BIOCHIMICA POLONICA, 2014, 61 (01) : 91 - 97
  • [5] Semiquantitative RT-PCR evaluation of the MDR1 gene expression in patients with acute myeloid leukemia
    Trnkova, Z.
    Bedrlikova, R.
    Markova, J.
    Michalova, K.
    Stoeckbauer, P.
    Schwarz, J.
    NEOPLASMA, 2007, 54 (05) : 383 - 390
  • [6] Real Time RT-PCR as a Tool for Quantitative Hevea Gene Expression Studies
    Bahari, Azlina
    Chow, K. S.
    JOURNAL OF RUBBER RESEARCH, 2011, 14 (01) : 51 - 64
  • [7] The quantification of prion gene expression in sheep using real-time RT-PCR
    Cai-Xia Han
    Hong-Xiang Liu
    De-Ming Zhao
    Virus Genes, 2006, 33 : 359 - 364
  • [8] Computational and Real-Time RT-PCR Expression Analyses of Garlic Lectin Gene
    Usman, Faiqa
    Rehman, Sameera
    Khan, Muhammad Ramzan
    Ali, Ghulam Muhammad
    INTERNATIONAL JOURNAL OF AGRICULTURE AND BIOLOGY, 2015, 17 (03) : 547 - 553
  • [9] Development of real-time RT-PCR assays for porcine cytokine gene expression
    Dawson, HD
    Beshah, E
    Nishii, S
    Lunney, JK
    Urban, JF
    FASEB JOURNAL, 2002, 16 (04): : A679 - A679
  • [10] Real-time RT-PCR methodology for quantification of thiopurine methyltransferase gene expression
    Lindqvist, M
    Almer, S
    Peterson, C
    Söderkvist, P
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2003, 59 (03) : 207 - 211
12345