Activation of MKK4 (SEK1), JNK, and c-Jun in labial salivary infiltrating T cells in patients with Sjogren's syndrome

被引：11
|
作者：
Soejima, Kazutaka [1 ]
Nakamura, Hideki [1 ]
Tamai, Mami [1 ]
Kawakami, Atsushi [1 ]
Eguchi, Katsumi [1 ]
机构：
[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Internal Med 1, Nagasaki 8528501, Japan
来源：
RHEUMATOLOGY INTERNATIONAL | 2007年 / 27卷 / 04期
关键词：
Sjogren's syndrome; MKK4; JNK; c-Jun;
D O I：
10.1007/s00296-006-0229-x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We wanted to determine via immunohistochemistry, whether or not c-Jun NH2-terminal kinase (JNK) cascade is activated in labial salivary infiltrating T cells in patients with Sjogren's syndrome (SS). Six patients with primary SS were selected for this study. Phosphorylation of mitogen-activated protein kinase (MAPK) kinase 4 (MKK4) (SEK1), JNK, and c-Jun in salivary infiltrating T cells was studied using immunohistochemistry assay, including mirror section technique. Phosphorylated forms of MKK4, JNK, and c-Jun were detected in salivary infiltrating mononuclear cells. Expression of phosphorylated JNK was found in both CD4+ T cells and CD8+ T cells. Moreover, co-expression of phosphorylated JNK and c-Jun was demonstrated in the mirror sections. The results of this study suggest that the JNK cascade is activated in salivary infiltrating CD4+ T cells and CD8+ T cells in SS patients, which appears to contribute to the inflammatory salivary microenvironment of SS.
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收藏
页码：329 / 333
页数：5
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