Multiple drug resistance-associated protein 4 (MRP4) may contribute to breast cancer metastasis by exporting the COX-2 product PGE2

被引：0
|
作者：
Kochel, Tyler J. [1 ]
Kundu, Namita [1 ]
Ma, Xinrong [1 ]
Reader, Jocelyn [1 ]
Fulton, Amy [1 ,2 ]
机构：
[1] Univ Maryland, Greenebaum Canc Ctr, Baltimore, MD 21201 USA
[2] VA Med Ctr, Baltimore, MD USA
来源：
CANCER RESEARCH | 2015年 / 75卷
关键词：
D O I：
10.1158/1538-7445.AM2015-2257
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2257
引用
收藏
页数：1
相关论文
共 50 条
  • [41] Herbal melanin modulates PGE2 and IL-6 gastroprotective markers through COX-2 and TLR4 signaling in the gastric cancer cell line AGS
    El-Obeid, Adila
    Maashi, Yahya
    Alroshody, Rehab
    Alatar, Ghada
    Aljudayi, Modhi
    Al-Eidi, Hamad
    Algaith, Nouf
    Khan, Altaf Husain
    Hassib, Adil
    Matou-Nasri, Sabine
    BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2023, 23 (01)
  • [42] Natural fulvic acids inhibit non-small-cell lung cancer through the COX-2/PGE2/EP4 axis: In silico and in vivo assessments
    Xin, Pengfei
    Wang, Shirui
    Xu, Xin
    Liu, Qingmei
    Zhang, Caifeng
    HELIYON, 2023, 9 (06)
  • [43] PGE2 promotes breast cancer-associated lymphangiogenesis by activation of EP4 receptor on lymphatic endothelial cells
    Pinki Nandi
    Gannareddy V. Girish
    Mousumi Majumder
    Xiping Xin
    Elena Tutunea-Fatan
    Peeyush K. Lala
    BMC Cancer, 17
  • [44] Impact of Abcc2 [Multidrug Resistance-Associated Protein (Mrp) 2], Abcc3 (Mrp3), and Abcg2 (Breast Cancer Resistance Protein) on the Oral Pharmacokinetics of Methotrexate and Its Main Metabolite 7-Hydroxymethotrexate
    Vlaming, Maria L. H.
    van Esch, Anita
    van de Steeg, Evita
    Pala, Zeliha
    Wagenaar, Els
    van Tellingen, Olaf
    Schinkel, Alfred H.
    DRUG METABOLISM AND DISPOSITION, 2011, 39 (08) : 1338 - 1344
  • [45] Multidrug resistance-associated protein 2 (MRP2) enhances 4-hydroxynonenal-induced toxicity in Madin-Darby canine kidney II cells
    Ji, B
    Ito, K
    Horie, T
    CHEMICAL RESEARCH IN TOXICOLOGY, 2004, 17 (02) : 158 - 164
  • [46] Multidrug Resistance-Associated Protein (MRP1, 2, 4 and 5) Expression in Human Corneal Cell Culture Models and Animal Corneal Tissue
    Verstraelen, Jessica
    Reichl, Stephan
    MOLECULAR PHARMACEUTICS, 2014, 11 (07) : 2160 - 2171
  • [47] Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model
    Xin, Xiping
    Majumder, Mousumi
    Girish, Gannareddy V.
    Mohindra, Vik
    Maruyama, Takayuki
    Lala, Peeyush K.
    LABORATORY INVESTIGATION, 2012, 92 (08) : 1115 - 1128
  • [48] Intestinal absorption mechanisms of 2′-deoxy-2′-β-fluoro-4′-azidocytidine, a cytidine analog for AIDS treatment, and its interaction with P-glycoprotein, multidrug resistance-associated protein 2 and breast cancer resistance protein
    Liu, Yixian
    Liu, Bingjie
    Zhang, Yan
    Peng, Youmei
    Huang, Chenzheng
    Wang, Ning
    Jiang, Jinhua
    Wang, Qingduan
    Chang, Junbiao
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 105 : 150 - 158
  • [49] Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells
    Kawase, Atsushi
    Inoue, Yuta
    Hirosoko, Miho
    Sugihara, Yuka
    Shimada, Hiroaki
    Iwaki, Masahiro
    JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 2019, 22 : 576 - 584
  • [50] Leflunomide Increases Hepatic Exposure to Methotrexate and Its Metabolite by Differentially Regulating Multidrug Resistance-Associated Protein Mrp2/3/4 Transporters via Peroxisome Proliferator-Activated Receptor α Activation
    Wang, Le
    Ma, Leilei
    Lin, Yunfei
    Liu, Xing
    Xiao, Ling
    Zhang, Yiting
    Xu, Ye
    Zhou, Hu
    Pan, Guoyu
    MOLECULAR PHARMACOLOGY, 2018, 93 (06) : 563 - 574
12345