The role of 14-3-3 proteins in cell signalling pathways and virus infection

被引：37
|
作者：
Liu, Jiaqi [1 ,2 ]
Cao, Shengliang [1 ,2 ]
Ding, Guofei [1 ,2 ]
Wang, Bin [1 ,2 ]
Li, Yingchao [1 ,2 ]
Zhao, Yuzhong [1 ,2 ]
Shao, Qingyuan [1 ,2 ]
Feng, Jian [1 ,2 ]
Liu, Sidang [1 ,2 ]
Qin, Liting [3 ,4 ]
Xiao, Yihong [1 ,2 ]
机构：
[1] Shandong Agr Univ, Coll Anim Sci & Vet Med, Dept Fundamental Vet Med, 61 Daizong St, Tai An 271018, Shandong, Peoples R China
[2] Shandong Agr Univ, Shandong Prov Key Lab Anim Biotechnol & Dis Contr, Tai An, Shandong, Peoples R China
[3] Shandong New Hope Liuhe Grp Co Ltd, Qingdao, Peoples R China
[4] Qingdao Jiazhi Biotechnol Co Ltd, Qingdao, Peoples R China
来源：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2021年 / 25卷 / 09期
基金：
中国国家自然科学基金;
关键词：
14‐ 3‐ 3; proteins; biological function; innate immunity; viral infection; DNA-DAMAGE CHECKPOINT; NF-KAPPA-B; RIG-I; KINASE; BINDING; PHOSPHORYLATION; TRANSCRIPTION; 14-3-3-PROTEINS; PHOSPHATASE; INHIBITION;
D O I：
10.1111/jcmm.16490
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
14-3-3 proteins are highly conserved in species ranging from yeast to mammals and regulate numerous signalling pathways via direct interactions with proteins carrying phosphorylated 14-3-3-binding motifs. Recent studies have shown that 14-3-3 proteins can also play a role in viral infections. This review summarizes the biological functions of 14-3-3 proteins in protein trafficking, cell-cycle control, apoptosis, autophagy and other cell signal transduction pathways, as well as the associated mechanisms. Recent findings regarding the role of 14-3-3 proteins in viral infection and innate immunity are also reviewed.
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页码：4173 / 4182
页数：10
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