The longevity effect of dietary restriction in Caenorhabditis elegans

被引：43
|
作者：
Houthoofd, Koen [1 ]
Vanfleteren, Jacques R. [1 ]
机构：
[1] Univ Ghent, Dept Biol, Univ Coll, B-9000 Ghent, Belgium
来源：
EXPERIMENTAL GERONTOLOGY | 2006年 / 41卷 / 10期
关键词：
dietary restriction; aging; Caenorhabditis elegans;
D O I：
10.1016/j.exger.2006.05.007
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The nematode Caenorhabditis elegans has been subjected to DR by food (Escherichia coli) dilution, growth in axenic medium and using animals having defects in feeding behavior or in specific nutrient transporter proteins. There is evidence that DR causes increased resistance against environmental stressors but no decrease of metabolic rate. The insulin/IGF-1 signaling pathway does not mediate the longevity effect of DR in this species, but TOR signaling may be involved. The metabolic stability-longevity theory offers a plausible explanation of the longevity effect of DR but needs experimental validation. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：1026 / 1031
页数：6
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