Chemoenzymatic dynamic kinetic resolution of secondary amines

被引:93
|
作者
Stirling, Matthew
Blacker, John
Page, Michael I. [1 ]
机构
[1] Univ Huddersfield, Dept Chem & Biol Sci, Huddersfield HD1 3DH, W Yorkshire, England
[2] NPILPharma, Huddersfield HD1 9GA, W Yorkshire, England
关键词
D O I
10.1016/j.tetlet.2006.12.032
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The kinetic resolution of amines using a novel iridium based catalyst coupled with an enzyme catalysed step is achieved on a large scale with high yields and ee. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1247 / 1250
页数:4
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