From bench to bedside: a diagnostics framework for pharmacogenetics research

被引：4
|
作者：
Katz, DA [1 ]
机构：
[1] Abbott Labs, Abbott Pk, IL 60064 USA
来源：
MOLECULAR GENETICS AND METABOLISM | 2002年 / 77卷 / 1-2期
关键词：
pharmacogenetics; genotype-phenotype correlations; clinical applications; molecular diagnostics;
D O I：
10.1016/S1096-7192(02)00143-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Although many genetic variants have been associated with differential drug responses, a very limited number of pharmacogenctic tests have entered common clinical practice. Pharmacogenetic tests that are successful address unmet medical needs, are clinically relevant, and have sufficient sensitivity, and specificity. In this respect, pharmacogenetics is no different from other diagnostics fields. Unmet medical need, clinical relevance, sensitivity, and specificity are discussed in the context of specific pharmacogenetic associations. These parameters are useful guides for researchers interested in translating pharmacogenetic findings from the bench to the bedside. (C) 2002 Elsevier Science (USA). All rights reserved.
引用
收藏
页码：57 / 60
页数：4
相关论文
共 50 条
  • [31] Clinical Research in Neurology: from Bench to Bedside
    Walter, U.
    Zettl, U. K.
    [J]. FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE, 2009, 77 : S1 - S2
  • [32] Urticaria: "From bench to bedside" [Urtikaria: "From bench to bedside"]
    Magerl M.
    Maurer M.
    [J]. Der Hautarzt, 2007, 58 (4): : 308 - 313
  • [33] The 'Action-Research' philosophy: from bedside to bench, to bedside again
    Beauchet, Olivier
    Fantino, Bruno
    Annweiler, Cedric
    [J]. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2012, 66 (05) : 517 - 517
  • [34] Peritoneal dialysis: from bench to bedside and bedside to bench
    Perl, Jeffrey
    Bargman, Joanne M.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2016, 311 (05) : F999 - F1004
  • [35] Takotsubo Syndrome: From Bench to Bedside and Bedside to Bench
    Pelliccia, Francesco
    Morgantini, Amalia
    Rosati, Riccardo
    [J]. JOURNAL OF CLINICAL MEDICINE, 2022, 11 (16)
  • [36] Growth Hormone and Translational Research: From the 'Bench' to the 'Bedside'
    Kopchick, John J.
    Berryman, Darlene E.
    Gosney, Elahu
    List, Edward O.
    [J]. ENDOCRINOLOGY AND METABOLISM, 2011, 26 (04) : 285 - 294
  • [37] Osteopathic Research Conference 2013: "From Bench to Bedside"
    Grogg, Stanley E.
    [J]. JOURNAL OF THE AMERICAN OSTEOPATHIC ASSOCIATION, 2013, 113 (08): : 592 - 592
  • [38] Exceptional Matters: clinical research from bedside to bench
    Peters, K
    [J]. CLINICAL MEDICINE, 2004, 4 (06) : 551 - 566
  • [39] Obesity research: Moving from bench to bedside to population
    Schmidt, Ann Marie
    [J]. PLOS BIOLOGY, 2023, 21 (12)
  • [40] Basic research for the clinical trainee: from bedside to bench
    Newberry, RD
    [J]. GASTROINTESTINAL ENDOSCOPY, 2005, 61 (07) : 869 - 870
12345