Regulation of cell death and cell survival gene expression during ovarian follicular development and atresia

被引:153
|
作者
Jiang, JY
Cheung, CKM
Wang, YF
Tsang, BK
机构
[1] Ottawa Civic Hosp, Ottawa Hlth Res Inst, Hormones Growth & Dev Unit, Ottawa, ON K1Y 4E9, Canada
[2] Univ Ottawa, Dept Obstet & Gynecol & Cellular & Mol Med, Div Reprod Med, Ottawa, ON, Canada
[3] Univ Ottawa, Reprod Biol Unit, Ottawa, ON, Canada
来源
关键词
gene expression; cell death; cell survival; Fas; FasL; TNF-alpha; FSH; XIAP; FLIP; PI3K; TGF-alpha; follicle; development; atresia; review;
D O I
10.2741/949
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mammalian ovarian follicular development and atresia is closely regulated by the cross talk of cell death and cell survival signals, which include endocrine hormones (gonadotropins) and intra-ovarian regulators (gonadal steroids, cytokines and growth factors). The fate of the follicle is dependent on a delicate balance in the expression and actions of factors promoting follicular cell proliferation, growth and differentiation and of those inducing programmed cell death (apoptosis). As an important endocrine hormone, FSH binds to its granulosa cell receptors and promotes ovarian follicle survival and growth not only by stimulating proliferation and estradiol secretion of these cells, but also inhibiting the apoptosis by up-regulating the expression of intracellular anti-apoptotic proteins, such as XIAP and FLIP. In addition, intra-ovarian regulators, such as TGF-alpha and TNF-alpha, also play an important role in the control of follicular development and atresia. In response to FSH, Estradiol-17 beta synthesized from the granulosa cells stimulates thecal expression of TGF-alpha, which in turn increases granulosa cell XIAP expression and proliferation. The death receptor and ligand, Fas and Fas ligand, are expressed in granulosa cells following gonadotropin withdrawal, culminating in caspase-mediated apoptosis and follicular atresia. In contrast, TNF-alpha has both survival and pro-apoptotic function in the follicle, depending on the receptor subtype activated, but has been shown to promote granulosa cell survival by increasing XIAP and FLIP expression via the IkappaB-NFkappaB pathway. The pro-apoptotic action of TNF-alpha is mediated through the activation of caspases, via its receptor- (i.e. Caspases-8 and -3) and mitochrondria(i.e. Caspase-9 and -3) death pathways. In the present manuscript, we have reviewed the actions and interactions of gonadotropins and intra-ovarian regulators in the control of granulosa cell fate and ultimately follicular destiny. We have highlighted the role and regulation of granulosa cell XIAP and FLIP expression, as well as their interactions with the death signaling pathways in the maintenance of granulosa cell survival during follicular development. We have provided strong evidence for these intracellular survival factors as key determinants for ovarian follicular destiny (growth versus atresia), the expression of which is regulated by a highly integrated endocrine, paracrine and autocrine mechanism. Further studies in these aspects will lead to a better understanding of the molecular and cellular regulation of follicular development and atresia, and provide invaluable insight into novel strategies in assisted reproduction in human infertility as well as in increasing reproductive efficiency in livestock industries.
引用
收藏
页码:D222 / D237A
页数:16
相关论文
共 50 条
  • [21] Regulation of cell survival during renal development
    Hammerman, MR
    PEDIATRIC NEPHROLOGY, 1998, 12 (07) : 596 - 602
  • [22] Regulation of granulosa cell proliferation and apoptosis during follicular development
    Maruo, T
    Laoag-Fernandez, JB
    Takekida, S
    Peng, X
    Deguchi, J
    Samoto, T
    Kondo, H
    Matsuo, H
    GYNECOLOGICAL ENDOCRINOLOGY, 1999, 13 (06) : 410 - 419
  • [23] Onset of steroidogenic enzyme gene expression during ovarian follicular development in sheep
    Logan, KA
    Juengel, JL
    McNatty, KP
    BIOLOGY OF REPRODUCTION, 2002, 66 (04) : 906 - 916
  • [24] Expression of inhibitor of apoptosis proteins (IAPs) in rat granulosa cells during ovarian follicular development and atresia
    Li, J
    Kim, JM
    Liston, P
    Li, M
    Miyazaki, T
    Mackenzie, AE
    Korneluk, RG
    Tsang, BK
    ENDOCRINOLOGY, 1998, 139 (03) : 1321 - 1328
  • [25] BRE modulates granulosa cell death to affect ovarian follicle development and atresia in the mouse
    Yeung, Cheung Kwan
    Wang, Guang
    Yao, Yao
    Liang, Jianxin
    Chung, Cheuk Yiu Tenny
    Chuai, Manli
    Lee, Kenneth Ka Ho
    Yang, Xuesong
    CELL DEATH & DISEASE, 2017, 8 : e2697 - e2697
  • [26] BRE modulates granulosa cell death to affect ovarian follicle development and atresia in the mouse
    Cheung Kwan Yeung
    Guang Wang
    Yao Yao
    Jianxin Liang
    Cheuk Yiu Tenny Chung
    Manli Chuai
    Kenneth Ka Ho Lee
    Xuesong Yang
    Cell Death & Disease, 2017, 8 : e2697 - e2697
  • [27] Stem cell factor modulates the expression of steroidogenesis related proteins and FSHR during ovarian follicular development
    Jin, X
    Han, CS
    Zhang, XS
    Yu, FQ
    Guo, SH
    Hu, ZY
    Liu, YX
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2005, 10 : 1573 - 1580
  • [28] Gene Expression Regulation and the Signal Transduction of Programmed Cell Death
    Deng, Yuxin
    Li, Kexin
    Yan, Wenxin
    Li, Ke
    Wang, Changshan
    CURRENT ISSUES IN MOLECULAR BIOLOGY, 2024, 46 (09) : 10264 - 10298
  • [29] Expression and regulation of genes associated with cell death during murine preimplantation embryo development
    Jurisicova, A
    Latham, KE
    Casper, RF
    Varmuza, SL
    MOLECULAR REPRODUCTION AND DEVELOPMENT, 1998, 51 (03) : 243 - 253
  • [30] Autophagy is involved in granulosa cell death and follicular atresia in ewe ovaries
    Scudieri, Aurora
    Valbonetti, Luca
    Peric, Tanja
    Cotticelli, Alessio
    Ramal-Sanchez, Marina
    Loi, Pasqualino
    Gioia, Luisa
    THERIOGENOLOGY, 2024, 226 : 236 - 242