Prognostic factors and expression of p53 and mdm-2 in uterine sarcomas

被引：10

作者：

Kim, S. H.

Kim, J. W. ^{[2
]}

Kim, Y. T.

Kim, J. H.

Yoon, B. S.

Ryu, H. S.

机构：

[1] Ajou Univ, Coll Med, Dept Obstet & Gynecol, Suwon 441749, South Korea

[2] Yonsei Univ, Coll Med, Inst Womens Life Sci, Dept Obstet & Gynecol,Womens Canc Clin, Seoul 120749, South Korea

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 2006年 / 95卷 / 03期

关键词：

uterine sarcoma; clinicopathologic prognostic factors; p53; protein; mdm-2;

D O I：

10.1016/j.ijgo.2006.03.031

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objectives: To evaluate the clinicopathologic prognostic factors of uterine sarcoma, and determine whether overexpression of p53 and mdm-2 proteins correlate with overall survival and prognostic factors. Methods: Thirty specimens from 43 patients with uterine sarcoma were available for slide review and evaluated by immunohistochemistry at Yonsei and Ajou University Medical Centers for the expression of p53 and mdm-2. Results: Overall survival was found to correlate to histologic type of uterine sarcoma, surgical stage, tumor grade, and mitotic index. Whereas 63% of the sarcomas expressed p53, with a significant correlation to overall survival, 60% expressed mdm-2, with a significant correlation to the mitotic index but not to overall survival. Conclusion: Histologic type, surgical stage, tumor grade, mitotic index, and p53 expression were prognostic factors of the overall survival of patients with uterine sarcoma. (c) 2006 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd.

引用

页码：272 / 277

页数：6

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