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Murine interferon-gamma inducible protein-10 (IP-10) secreted by Lactococcus lactis chemo-attracts human CD3+lymphocytes

被引：2
|
作者：
Villatoro-Hernandez, Julio [1 ,6 ]
Yolanda Arce-Mendoza, Alma [2 ]
Rosas-Taraco, Adrian G. [2 ]
Cecilia Esparza-Gonzalez, Sandra [1 ]
Guzman-Lopez, Santos [3 ]
Elizondo-Omana, Rodrigo E. [3 ]
Chavez-Reyes, Arturo [4 ]
Saucedo-Cardenas, Odila [1 ,5 ]
Montes de Oca Luna, Roberto [1 ]
机构：
[1] UANL, Dept Histol, Monterrey 64460, NL, Mexico
[2] UANL, Serv Inmunol, Monterrey 64460, NL, Mexico
[3] UANL, Fac Med, Dept Anat Humana, Monterrey 64460, NL, Mexico
[4] Ctr Invest & Estudios Avanzados IPN, Unidad Monterrey, Apodaca 66600, NL, Mexico
[5] IMSS, Ctr Invest Biomed Noreste, Div Genet, Monterrey, NL, Mexico
[6] Kluyver Ctr Genom Ind Fermentat, NL-2600 GA Delft, Netherlands
来源：
BIOTECHNOLOGY LETTERS | 2009年 / 31卷 / 11期
关键词：
Chemotaxis; Human lymphocytes; Lactococcus lactis; Murine IP-10; GENE-EXPRESSION SYSTEM; RECEPTOR CXCR3; ACID BACTERIA; NISIN; DELIVERY; MUCOSAL; 6CKINE; USP45;
D O I：
10.1007/s10529-009-0081-7
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Chemokines are members of the super family of cytokines necessary for leukocyte recruitment in tissues and lymphoid organs. The interferon-gamma inducible protein-10 (IP-10) chemo-attracts CXCR3-expressing cells, such as activated T lymphocytes and monocytes. We have genetically engineered a strain of Lactococcus lactis to secrete a biologically active murine IP-10 that interacts with human CXCR3, its homolog receptor, and chemo-attracts human CD3+ T lymphocytes.
引用
收藏
页码：1795 / 1800
页数：6
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