Subcellular mRNA Localization in Animal Cells and Why It Matters

被引：294

作者：

Holt, Christine E. ^{[2
]}

Bullock, Simon L. ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Div Cell Biol, Cambridge CB2 0QH, England

[2] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3DY, England

来源：

SCIENCE | 2009年 / 326卷 / 5957期

基金：

英国惠康基金;

关键词：

XENOPUS-OOCYTES; PROTEIN-SYNTHESIS; ACTIN; TRANSLATION; TRANSPORT; DROSOPHILA; REVEALS; TRAFFICKING; TRANSLOCATION; DETERMINANTS;

D O I：

10.1126/science.1176488

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Subcellular localization of messenger RNAs (mRNAs) can give precise control over where protein products are synthesized and operate. However, just 10 years ago many in the broader cell biology community would have considered this a specialized mechanism restricted to a very small fraction of transcripts. Since then, it has become clear that subcellular targeting of mRNAs is prevalent, and there is mounting evidence for central roles for this process in many cellular events. Here, we review current knowledge of the mechanisms and functions of mRNA localization in animal cells.

引用

页码：1212 / 1216

页数：5

共 50 条

[31] Subcellular and regional localization of mRNA translation in midbrain dopamine neurons
Hobson, Benjamin D.
Kong, Linghao
Angelo, Maria Florencia
Lieberman, Ori J.
Mosharov, Eugene V.
Herzog, Etienne
Sulzer, David
Sims, Peter A.
CELL REPORTS, 2022, 38 (02):
[32] Subcellular mRNA localization across tissue architecture and polarity type
Mason, D.
Mili, S.
MOLECULAR BIOLOGY OF THE CELL, 2023, 34 (02) : 182 - 182
[33] Principles and roles of mRNA localization in animal development
Medioni, Caroline
Mowry, Kimberly
Besse, Florence
DEVELOPMENT, 2012, 139 (18): : 3263 - 3276
[34] mRNA stability and m6A are major determinants of subcellular mRNA localization in neurons
Loedige, Inga
Baranovskii, Artem
Mendonsa, Samantha
Dantsuji, Sayaka
Popitsch, Niko
Breimann, Laura
Zerna, Nadja
Cherepanov, Vsevolod
Milek, Miha
Ameres, Stefan
Chekulaeva, Marina
MOLECULAR CELL, 2023, 83 (15) : 2709 - +
[35] mRNA-CLA: An interpretable deep learning approach for predicting mRNA subcellular localization
Chen, Yifan
Du, Zhenya
Ren, Xuanbai
Pan, Chu
Zhu, Yangbin
Li, Zhen
Meng, Tao
Yao, Xiaojun
METHODS, 2024, 227 : 17 - 26
[36] mRNA Localization in Plant Cells
Tian, Li
Chou, Hong-Li
Fukuda, Masako
Kumamaru, Toshihiro
Okita, Thomas W.
PLANT PHYSIOLOGY, 2020, 182 (01) : 97 - 109
[37] Endoplasmic reticulum-directed recombinant mRNA displays subcellular localization equal to endogenous mRNA during transient expression in CHO cells
Kallehauge, Thomas Beuchert
Kol, Stefan
Andersen, Mikael Rordam
Damgaard, Christian Kroun
Lee, Gyun Min
Kildegaard, Helene Faustrup
BIOTECHNOLOGY JOURNAL, 2016, 11 (10) : 1362 - 1367
[38] Creaturely Cosmologies: Why Metaphysics Matters for Animal and Planetary Liberation
Marovich, Beatrice Eleanor
SOCIETY & ANIMALS, 2017, 25 (03) : 313 - 317
[39] Why animal experimentation matters: The use of animals in medical research
Shaw, WH
NATURE, 2001, 414 (6862) : 396 - 397
[40] Why Animal Suffering Matters: Philosophy, Theology, and Practical Ethics
Raterman, Ty
ENVIRONMENTAL ETHICS, 2010, 32 (04) : 425 - 428

← 1 2 3 4 5 →