Structure-activity relationship studies of flavopiridol analogues

被引：51
|
作者：
Murthi, KK
Dubay, M
McClure, C
Brizuela, L
Boisclair, MD
Worland, PJ
Mansuri, MM
Pal, K
机构：
[1] Mitotix Inc, Dept Med Chem, Cambridge, MA 02139 USA
[2] Mitotix Inc, Dept Biochem, Cambridge, MA 02139 USA
[3] Mitotix Inc, Dept Screening, Cambridge, MA 02139 USA
[4] Mitotix Inc, Dept Pharmacol, Cambridge, MA 02139 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 10期
关键词：
D O I：
10.1016/S0960-894X(00)00156-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cyclin dependent kinases (CDKs) along with the complementary cyclins form key regulatory checkpoint controls on the cell cycle. Flavopiridol is a synthetic flavone that shows potent and selective cyclin-dependent kinase inhibitory activity. In this paper, we report modifications of the 3-hydroxy-1-methylpiperidinyl (D ring) of flavopiridol and their effect on CDK inhibitory activity. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1037 / 1041
页数：5
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