Studies on structure-activity relationship of epibatidine and its analogues

被引：0

作者：

Xu, JP

He, D

Wang, ZZ

Shen, JC

Gao, LX

Song, YR

机构：

[1] CHANGCHUN INST APPL CHEM,CHANGCHUN,PEOPLES R CHINA

[2] BEIJING NORMAL UNIV,DEPT CHEM,BEIJING 100875,PEOPLES R CHINA

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 1996年 / 17卷 / 12期

关键词：

epibatidine; AM1; alkaloid; structure-activity relationship;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This paper reported the investigation of structure-activity relationship of the strong analgetic alkaloid epibatidine and it's analogues by using AM1 method. Some information was given according to the calculation results of HOMO electron density and electron charge distribution etc. It is also indicated that the biophores were the bridge nitrogen and exo-pyridine moiety of these alkaloids.

引用

页码：1893 / 1895

页数：3

共 6 条

[1] BERGEL F, 1994, JCS, P269
[2] TOTAL SYNTHESIS OF EPIBATIDINE
BROKA, CA
[J]. TETRAHEDRON LETTERS, 1993, 34 (20) : 3251 - 3254
[3] STEREOCONTROLLED TOTAL SYNTHESIS OF (+)-EPIBATIDINE AND (-)-EPIBATIDINE
COREY, EJ
LOH, TP
ACHYUTHARAO, S
DALEY, DC
SARSHAR, S
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (21): : 5600 - 5602
[4] Daly J. W., 1992, J AM CHEM SOC, V114, P3475
[5] TOTAL SYNTHESIS AND DETERMINATION OF THE ABSOLUTE-CONFIGURATION OF EPIBATIDINE
FLETCHER, SR
BAKER, R
CHAMBERS, MS
HERBERT, RH
HOBBS, SC
THOMAS, SR
VERRIER, HM
WATT, AP
BALL, RG
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (07): : 1771 - 1778
[6] SYNTHESIS OF (+)-EPIBATIDINE AND (-)-EPIBATIDINE
KOTIAN, PL
CARROLL, FI
[J]. SYNTHETIC COMMUNICATIONS, 1995, 25 (01) : 63 - 71

← 1 →