Advances in Hyaluronic Acid-Based Drug Delivery Systems

被引：50
|
作者：
Jiao, Yan [1 ]
Pang, Xin [1 ]
Zhai, Guangxi [1 ]
机构：
[1] Shandong Univ, Coll Pharm, Dept Pharmaceut, 44 Wenhua Xilu, Jinan 250012, Peoples R China
来源：
CURRENT DRUG TARGETS | 2016年 / 17卷 / 06期
关键词：
CD44; chemical modification; conjugates; derivatives; hyaluronic acid; nanocarriers; SELF-ASSEMBLED NANOPARTICLES; INTRACELLULAR DELIVERY; PULMONARY DELIVERY; TARGETED DELIVERY; DOXORUBICIN; PACLITAXEL; CARRIER; POLYSACCHARIDE; DEGRADATION; LIPOSOMES;
D O I：
10.2174/1389450116666150531155200
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Hyaluronic acid (HA) is a relatively new polymer for the construction of drug delivery systems. CD44 and the receptor for HA-mediated motility play a key role in vivo for the receptor-mediated endocytosis of HA. Cellular uptake and the efficiency of tumor-targeted drug delivery are supposed to increase through utilizing HA as drug carriers. Currently, HA has provided a promising platform to physically encapsulate or chemically conjugate with various drugs. In this review, we presented the most latest advances in HA-based drug delivery systems and some forward-looking ideas are discussed.
引用
收藏
页码：720 / 730
页数：11
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