Time-dependent effect of glutamate on long-term potentiation in the suprachiasmatic nucleus of rats

被引:9
|
作者
Nisikawa, Y
Shimazoe, T [1 ]
Shibata, S
Watanabe, S
机构
[1] Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Pharmacol, Fukuoka 8128582, Japan
[2] Waseda Univ, Fac Human Sci, Dept Pharmacol, Tokrozawa 3591192, Japan
来源
JAPANESE JOURNAL OF PHARMACOLOGY | 2002年 / 90卷 / 02期
关键词
glutamate; suprachiasmatic nucleus; long-term potentiation;
D O I
10.1254/jjp.90.201
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effect of glutamate on optic nerve stimulation-evoked field potentials in rat suprachiasmatic nucleus (SCN) was examined in vitro. Glutamate application for 20 min induced long-term potentiation (LTP) of the field potentials in the SCN at nighttime, whereas that induced a weak LTP at daytime. On the other hand, application for 40 min induced LP in the SCN during the daytime, whereas it induced a weak one at nighttime. These results indicate that the effect of glutamate is dependent on the application time and that the effect is influenced by the duration of glutamate exposure.
引用
收藏
页码:201 / 204
页数:4
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