How Pathogens Feel and Overcome Magnesium Limitation When in Host Tissues

被引：14

作者：

Blanc-Potard, Anne-Beatrice ^{[1
,2
]}

Groisman, Eduardo A. ^{[3
,4
]}

机构：

[1] Univ Montpellier, Lab Pathogen Host Interact, Case 107,Pl Eugene Bataillon, F-34095 Montpellier 5, France

[2] CNRS, UMR5235, F-34095 Montpellier 05, France

[3] Yale Sch Med, Dept Microbial Pathogenesis, 295 Congress Ave, New Haven, CT 06536 USA

[4] Yale Microbial Sci Inst, POB 27389, West Haven, CT 06516 USA

来源：

TRENDS IN MICROBIOLOGY | 2021年 / 29卷 / 02期

关键词：

magnesium; microbial pathogenesis; nutritional immunity; Salmonella; Slc11a1;

D O I：

10.1016/j.tim.2020.07.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Host organisms utilize nutritional immunity to limit the availability of nutrients essential to an invading pathogen. Nutrients may include amino acids, nucleotide bases, and transition metals, the essentiality of which varies among pathogens. The mammalian macrophage protein Slc11a1 (previously Nramp1) mediates resistance to several intracellular pathogens. Slc11a1 is proposed to restrict growth of Salmonella enterica serovar Typhimurium in host tissues by causing magnesium deprivation. This is intriguing because magnesium is the most abundant divalent cation in all living cells. A pathogen's response to factors such as Slc11a1 that promote nutritional immunity may therefore reflect what the pathogen 'feels' in its cytoplasm, rather than the nutrient concentration in host cell compartments.

引用

页码：98 / 106

页数：9

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