Correlation studies of miR-126 and inflammatory factors in peripheral blood of patients with coronary heart disease

Objective: To explore the correlation and the clinical significance of the miR-126 level and the level of inflammatory factor in peripheral blood of patients with coronary heart disease (CHD). Methods: One hundred and seven patients with CHD were selected as the observation group, and 107 healthy people were selected as the control group. The levels of miR-126, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), matrix metalloproteinase-9 (MMP-9), soluble vascular endothelial cell adhesion molecule-1 (sVCAM-1), N-terminal B-type natriuretic peptide precursor (NT-proBNP) and left ventricular ejection fraction percentage (LVEF%) in peripheral blood were compared between the two groups. According to the Gensini score, the observation group was divided into high and low integral groups, and the index levels of the two groups were compared. And the correlation between miR-126 and serum CRP, IL-6, TNF-alpha, MMP-9, sVCAM-1, NT-proBNP and LVEF% was analyzed. The patients were followed up for half a year and divided into poor prognosis group and good prognosis group according to the prognosis. The levels of various indexes in the two groups were compared, and the value of miR-126 in predicting the prognosis of patients was analyzed. Results: Compared with the control group, the observation group had lower levels of miR-126 and LVEF%, but higher levels of CRP, IL-6, TNF-alpha, MMP-9, sVCAM-1, and NT-proBNP (all P<0.001). Compared with the low score group, the high score group had lower levels of miR-126 and LVEF%, and higher levels of CRP, IL-6, TNF-alpha, MMP-9, sVCAM-1 and NT-proBNP (all P<0.001). Compared with the better prognosis group, the poor prognosis group had lower levels of miR-126 and LVEF%, and higher levels of CRP, IL-6, TNF-alpha, MMP-9, sVCAM-1, and NT-proBNP (all P<0.001). MiR-126 was positively correlated with LVEF%, and negatively correlated with CRP, IL-6, TNF-alpha, MMP-9, sVCAM-1 and NT-proBNP (all P<0.001). The results of ROC curve showed that miR126 was more than 0.800 in evaluating the prognosis of CHD. Conclusion: The level of miR-126 in peripheral blood of patients with CHD decreased significantly, which was negatively correlated with the severity of the disease and inflammatory reaction, and had high clinical value in evaluating the prognosis.