Palladium-catalyzed, aminoquinoline-directed arylation of phosphonamidate and phosphinic amide sp3 C-H bonds

被引：15
|
作者：
Tung Thanh Nguyen [1 ]
Daugulis, Olafs [1 ]
机构：
[1] Univ Houston, Dept Chem, Univ Pk, Houston, TX 77204 USA
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 33期
关键词：
CARBON-HYDROGEN BONDS; CYCLIZATION; ACTIVATION; FUNCTIONALIZATION; ALKYLATION; PHENOLS; OXIDES; SP(2); SCOPE;
D O I：
10.1039/c7cc02063e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Aminoquinoline-directed, palladium-catalyzed sp(3) C-H bond arylation in phosphonamidates and phosphinic amides is reported. The reaction employs Pd(OAc)(2) as a catalyst at 10 mol% loading and cesium phosphate or potassium carbonate as a base in 1,2-dichlorobenzene as a solvent. The directing group can be removed under basic conditions to afford phosphonic acid esters. The chemistry described here is the first example of unactivated sp(3) C-H bond arylation by using a phosphorus-containing directing group.
引用
收藏
页码：4609 / 4611
页数：3
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