Psoriasis - as an autoimmune disease caused by molecular mimicry

被引：132

作者：

Valdimarsson, Helgi ^{[1
]}

Thorleifsdottir, Ragna H. ^{[1
]}

Sigurdardottir, Sigrun L. ^{[1
]}

Gudjonsson, Johann E. ^{[2
]}

Johnston, Andrew ^{[2
]}

机构：

[1] Landspitali Univ Hosp, Dept Immunol, Reykjavik, Iceland

[2] Univ Michigan, Dept Dermatol, Sch Med, Ann Arbor, MI 48109 USA

来源：

TRENDS IN IMMUNOLOGY | 2009年 / 30卷 / 10期

关键词：

CHRONIC PLAQUE PSORIASIS; T-CELL RESPONSES; SKIN-LESIONS; IMMUNE-RESPONSE; KERATIN; 17; IFN-GAMMA; IN-VITRO; ANTIGEN; VULGARIS; PEPTIDOGLYCAN;

D O I：

10.1016/j.it.2009.07.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Psoriasis is strongly associated with streptococcal throat infection, and patients have increased occurrence of such infections. Psoriatic lesional T cells are oligoclonal, and T cells recognizing determinants common to streptococcal M-protein and keratin have been detected in patients' blood. We propose that CD8(+) T cells in psoriatic epidermis respond mainly to such determinants, whereas CD4(+) T cells in the dermis preferentially recognize determinants on the streptococcal peptidoglycan that might itself act as an adjuvant. The streptococcal association might reflect the concurrence of superantigen production promoting skin-homing of tonsil T cells, M-protein mimicking keratin determinants, and adjuvant effects of the peptidoglycan. Accordingly, improvement of psoriasis after tonsillectomy should be associated with fewer T cells that recognize keratin and streptococcal determinants.

引用

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页码：494 / 501

页数：8

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