Ru(II)-Catalyzed Tunable Cascade Reaction via C-H/C-C Bond Cleavage

被引：17
|
作者：
Yang, Zi [1 ]
Yue, Qi [1 ]
Yang, Mengqi [1 ]
Zhang, Hong [1 ]
Cui, Xiuling [1 ]
机构：
[1] Huaqiao Univ, Dept Engn,Sch Biomed Sci, Res Ctr Mol Med,Key Lab Precis Med & Mol Diag Fuj, Minist Educ,Key Lab Fujian Mol Med,Key Lab Xiamen, Xiamen 361021, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 20期
关键词：
H ACTIVATION; FUNCTIONALIZATION; CYCLIZATION; ANNULATION; DEUTERIUM; EFFICIENT; ALKYNES; NITRILES; STRATEGY;
D O I：
10.1021/acs.joc.0c01614
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile synthesis of various 3-(alkoxyalkyl)-1H-indoles from pyrazolidinones, 2-acetylenic ketones, and alkyl alcohols via C-H/C-C bond activation has been developed. The reaction proceeds smoothly under the proper reaction conditions, and preliminary mechanistic studies suggest that NaOAc is crucial for C-C bond activation. The advantages of the present method represent a redox-neutral process and exhibit excellent chemo and regioselectivity.
引用
收藏
页码：12960 / 12970
页数：11
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