Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry

被引：16

作者：

Howell, Lesley A. ^{[1
]}

Howman, Aaron ^{[1
]}

O'Connell, Maria A. ^{[1
]}

Mueller, Anja ^{[1
]}

Searcey, Mark ^{[1
]}

机构：

[1] Univ E Anglia, Sch Pharm, Norwich NR4 7TJ, Norfolk, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 20期

关键词：

DNA; Threading intercalators; Acridines; Benzyne click chemistry; TOPOISOMERASE-II; CRYSTAL-STRUCTURE; AGENTS; AZIDES; D(CGTACG)(2); BINDING;

D O I：

10.1016/j.bmcl.2009.08.070

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A small set of 9-aminoacridine-3- and 4-carboxamides were synthesized efficiently using the benzyne/azide click chemistry. The products bind to duplex DNA but have different antitumour activity in the HL60 cell line. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：5880 / 5883

页数：4

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